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Nonequilibrium biochemical structures in two space dimensions with local activation and regulation

Abstract : Integrin receptor (IR) clustering is an example of pattern self-organization in biological systems. We study a model for receptor activation whose content is guided by two major principles in cellular signal transduction: (i) Proteins cycle between different conformational states; (ii) The dynamics of their conformational dynamics is environment dependent. Based on a simple activation pathway where these two hypotheses are formulated in a self-consistent way, this paper focuses mainly on stochastic simulations valid in the limit of a small number of molecules. It is shown that coherent clustering can lead to digital signaling and receptor competition in biochemical systems where the model gives a recruitment mechanism for the reinforcement of the mechanical linkage with the extracellular matrix. Together with previous works, this paper provides a workable model for cell integrin adhesive structures when feedback mediated by membrane diffusing signals is dominant. Consequences are discussed in the framework of published data concerning the local production of a key phospholipid for cell signaling (PIP 2).
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https://hal.archives-ouvertes.fr/hal-02465425
Contributor : Bertrand Fourcade <>
Submitted on : Monday, February 3, 2020 - 8:40:28 PM
Last modification on : Tuesday, July 28, 2020 - 6:18:27 PM
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Bertrand Fourcade. Nonequilibrium biochemical structures in two space dimensions with local activation and regulation. Physical Review E , American Physical Society (APS), 2020, 101 (1), ⟨10.1103/PhysRevE.101.012420⟩. ⟨hal-02465425⟩

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