Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

The modeled structure of the RNA dependent RNA polymerase of GBV-C virus suggests a role for motif E in Flaviviridae RNA polymerases.

Abstract : The Flaviviridae virus family includes major human and animal pathogens. The RNA dependent RNA polymerase (RdRp) plays a central role in the replication process, and thus is a validated target for antiviral drugs. Despite the increasing structural and enzymatic characterization of viral RdRps, detailed molecular replication mechanisms remain unclear. The hepatitis C virus (HCV) is a major human pathogen difficult to study in cultured cells. The bovine viral diarrhea virus (BVDV) is often used as a surrogate model to screen antiviral drugs against HCV. The structure of BVDV RdRp has been recently published. It presents several differences relative to HCV RdRp. These differences raise questions about the relevance of BVDV as a surrogate model, and cast novel interest on the "GB" virus C (GBV-C). Indeed, GBV-C is genetically closer to HCV than BVDV, and can lead to productive infection of cultured cells. There is no structural data for the GBV-C RdRp yet.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-02459250
Contributor : Helene Dutartre Connect in order to contact the contributor
Submitted on : Wednesday, January 29, 2020 - 11:50:52 AM
Last modification on : Tuesday, October 19, 2021 - 10:59:50 PM

Links full text

Identifiers

Citation

Francois Ferron, Cécile Bussetta, Hélène Dutartre, Bruno Canard. The modeled structure of the RNA dependent RNA polymerase of GBV-C virus suggests a role for motif E in Flaviviridae RNA polymerases.. BMC Bioinformatics, BioMed Central, 2005, 6 (1), pp.255. ⟨10.1186/1471-2105-6-255⟩. ⟨hal-02459250⟩

Share

Metrics

Record views

24