Lactobacilli-Host mutualism: "learning on the fly"

Renata Matos (1) , François Leulier (2)

1 ITQB - Instituto de Tecnologia Química e Biológica António Xavier
2 IGFL - Institut de Génomique Fonctionnelle de Lyon

Metazoans establish with microorganisms complex interactions for their mutual benefits. Drosophila, which has already proven useful host model to study several aspects of innate immunity and host-bacteria pathogenic associations has become a powerful model to dissect the mechanisms behind mutualistic host-microbe interactions. Drosophila microbiota is composed of simple and aerotolerant bacterial communities mostly composed of Lactobacillaceae and Acetobactereaceae. Drosophila mono-or poly-associated with lactobacilli strains constitutes a powerful model to dissect the complex interplay between lactobacilli and host biologic traits. Thanks to the genetic tractability of both Drosophila and lactobacilli this association model offers a great opportunity to reveal the underlying molecular mechanisms. Here, we review our current knowledge about how the Drosophila model is helping our understanding of how lactobacilli shapes host biology.

Domaines: Sciences du Vivant [q-bio]

Renata Matos, François Leulier. Lactobacilli-Host mutualism: "learning on the fly". Microbial Cell Factories, 2014, Proceedings of the 11th International Symposium on Lactic Acid Bacteria, 13 (supplement 1). ⟨hal-02444104⟩