Calcium phosphate nanocoatings and nanocomposites, part 2: thin films for slow drug delivery and osteomyelitis

Besim Ben-Nissan (1) , Innocent Macha (1) , Sophie Cazalbou (2) , Andy H Choi (1)

1 UTS - University of Technology Sydney
2 CIRIMAT - Centre interuniversitaire de recherche et d'ingenierie des matériaux

During the last two decades although many calcium phosphate based nanomaterials have been proposed for both drug delivery, and bone regeneration, their coating applications have been somehow slow due to the problems related to their complicated synthesis methods. In order to control the efficiency of local drug delivery of a biomaterial the critical pore sizes as well as good control of the chemical composition is pertinent. A variety of calcium phosphate based nanocoated composite drug delivery systems are currently being investigated. This review aims to give an update into the advancements of calcium phosphate nanocoatings and thin film nanolaminates. In particular recent research on PLA/hydroxyapatite composite thin films and coatings into the slow drug delivery for the possible treatment of osteomyelitis is covered.

Mots clés: Antibiotics; Biofilm; Drug delivery; Hydroxyapatite; Nanocoatings; Nanocomposites; Nanolaminates; Osteomyelitis; Thin films

Domaines: Matériaux

Besim Ben-Nissan, Innocent Macha, Sophie Cazalbou, Andy H Choi. Calcium phosphate nanocoatings and nanocomposites, part 2: thin films for slow drug delivery and osteomyelitis. Nanomedicine, 2016, 11 (5), pp.531-544. ⟨10.2217/nnm.15.220⟩. ⟨hal-02430692⟩