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Intraoperative quantitative functional brain mapping using an RGB camera

Charly Caredda 1 Laurent Mahieu-Williame 2 Raphaël Sablong 1 Michaël Sdika 3 Laure Alston 1 Jacques Guyotat 4 Bruno Montcel 1
1 RMN et optique : De la mesure au biomarqueur
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
2 PILoT - Plateforme d'Imagerie Multimodale LyonTech
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
3 MYRIAD - Modeling & analysis for medical imaging and Diagnosis
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
Abstract : Intraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. However, it still lacks robustness to be used as a clinical standard. In particular, new biomarkers of brain functionality with improved sensitivity and specificity are needed. We present a method for the computation of hemodynamics-based functional brain maps using an RGB camera and a white light source. We measure the quantitative oxy and deoxyhemoglobin concentration changes in the human brain cortex with the modified Beer-Lambert law and Monte Carlo simulations. A functional model has been implemented to evaluate the functional brain areas following neuronal activation by physiological stimuli. The results show a good correlation between the computed quantitative functional maps and the brain areas localized by electrical brain stimulation (EBS). We demonstrate that an RGB camera combined with a quantitative modeling of brain hemodynamics biomarkers can evaluate in a robust way the functional areas during neurosurgery and serve as a tool of choice to complement EBS. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Submitted on : Tuesday, January 7, 2020 - 11:46:20 AM
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Charly Caredda, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Laure Alston, et al.. Intraoperative quantitative functional brain mapping using an RGB camera. Neurophotonics, 2019, 6 (04), pp.1. ⟨10.1117/1.NPh.6.4.045015⟩. ⟨hal-02425832⟩

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