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Article Dans Une Revue Journal of Enzyme Inhibition and Medicinal Chemistry Année : 2017

Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?

Résumé

Carbonic anhydrases have started to emerge as new potential antibacterial targets for several pathogens. Two β-carbonic anhydrases, denominated bsCA I and bsCA II, have been isolated and characterized from the bacterial pathogen Brucella suis, the causative agent of brucellosis or Malta fever. These enzymes have been investigated in detail and a wide range of classical aromatic and heteroaromatic sulfonamides as well as carbohydrate-based compounds have been found to inhibit selectively and efficiently Brucella suis carbonic anhydrases. Inhibition of these metalloenzymes constitutes a novel approach for the potential development of new anti-Brucella agents. This review aims at discussing the recent literature on this topic.
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Dates et versions

hal-02425103 , version 1 (08-01-2020)

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Stephan Köhler, Safia Ouahrani-Bettache, Jean-Yves Winum. Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?. Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 32 (1), pp.683-687. ⟨10.1080/14756366.2017.1295451⟩. ⟨hal-02425103⟩
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