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Deviations in cortex sulcation associated with visual hallucinations in schizophrenia

Abstract : Hallucinations, and auditory hallucinations (AH) in particular, constitute the most typical and disabling schizophrenia symptoms. Although visual hallucinations (VH) have been largely neglected in psychiatric disorders, a recent review reported a 27% mean prevalence of VH in schizophrenia patients. The pathophysiology underlying VH in schizophrenia remains elusive. Several schizophrenia studies reported a significant effect of age on VH; therefore, we tested the hypothesis that the neurodevelopmental model of schizophrenia may explain VH occurrence. We analyzed cortex sulcation, a marker of brain development, in healthy controls (HCs) and two subgroups of carefully selected schizophrenia patients suffering from hallucinations: patients with only AH (that is, patients who never reported VH) and patients with audio-visual hallucinations (A+VH). Different cortical sulcation and left-right sulcal asymmetry were found between A+VH and AH patients, with decreased sulcation in both A+VH and AH patients in comparison with the HCs. Although a specific association between VH and neurodegenerative mechanisms, for example, in Body-Lewy Dementia or Parkinson's Disease, has previously been reported in the literature, the current study provides the first neuroimaging evidence of an association between VH and neurodevelopmental mechanisms.
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https://hal.univ-lille.fr/hal-02416615
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Submitted on : Tuesday, December 17, 2019 - 5:37:23 PM
Last modification on : Wednesday, March 23, 2022 - 3:51:20 PM

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A. Cachia, Ali Amad, J. Brunelin, M.-O. Krebs, M. Plaze, et al.. Deviations in cortex sulcation associated with visual hallucinations in schizophrenia. Mol Psychiatry, 2015, Molecular psychiatry, 20 (9), pp.1101-1107. ⟨10.1038/mp.2014.140⟩. ⟨hal-02416615⟩

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