MAPK signaling is necessary for neurogenesis in Nematostella vectensis

MAPK signaling is necessary for neurogenesis in Nematostella vectensis.

Michael Layden (1) , Hereroa Johnston (2) , Aldine R Amiel (3) , Jamie Havrilak , Bailey Steinworth , Taylor Chock (4) , Eric Röttinger (2) , Mark Q Martindale (4)

1 Lehigh University [Bethlehem]
2 IRCAN - Institut de Recherche sur le Cancer et le Vieillissement
3 LBDV - Laboratoire de Biologie du Développement de Villefranche sur mer
4 The Whitney Laboratory for Marine Bioscience [St. Augustine, FL, USA]

The nerve net of Nematostella is generated using a conserved cascade of neurogenic transcription factors. For example, NvashA, a homolog of the achaete-scute family of basic helix-loop-helix transcription factors, is necessary and sufficient to specify a subset of embryonic neurons. However, positive regulators required for the expression of neurogenic transcription factors remain poorly understood.

Domaines: Sciences du Vivant [q-bio]; Biologie du développement

Michael Layden, Hereroa Johnston, Aldine R Amiel, Jamie Havrilak, Bailey Steinworth, et al.. MAPK signaling is necessary for neurogenesis in Nematostella vectensis. BMC Biology, 2016, 14 (1), pp.61. ⟨10.1186/s12915-016-0282-1⟩. ⟨hal-02411354⟩