Peripheral Plasma and Semen Cytokine Response to Zika Virus in Humans

Jean-Michel Mansuy (1) , Hicham El Costa (1, 2) , Jordi Gouilly (2) , Catherine Mengelle (1) , Christophe Pasquier (1) , Guillaume Martin-Blondel (2, 1) , Jacques Izopet (1, 2) , Nabila Jabrane-Ferrat (2)

1 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
2 CPTP - Centre de Physiopathologie Toulouse Purpan

We assessed Zika virus RNA and select cytokine levels in semen, blood, and plasma samples from an infected patient in South America. Viral RNA was detected in semen >2 months after viremia clearance; cytokine profiles differed in semen and plasma. After viremia, Zika virus appears to become compartmentalized in the male reproductive tract.

Domaines: Maladies infectieuses; Maladies émergentes; Immunité innée; Immunité adaptative; Sciences du Vivant [q-bio]

Jean-Michel Mansuy, Hicham El Costa, Jordi Gouilly, Catherine Mengelle, Christophe Pasquier, et al.. Peripheral Plasma and Semen Cytokine Response to Zika Virus in Humans. Emerging Infectious Diseases, 2019, 25 (4), pp.823-825. ⟨10.3201/eid2504.171886⟩. ⟨hal-02405546⟩