Antibiotic Containing Poly Lactic Acid/Hydroxyapatite Biocomposite Coatings for Dental Implant Applications

Ipek Karacan (1) , Innocent Jacob Macha (2) , Gina Choi (1) , Sophie Cazalbou (3) , Besim Ben-Nissan (1)

1 UTS - University of Technology Sydney
2 UDSM - Université de Dar es Salaam
3 CIRIMAT - Centre interuniversitaire de recherche et d'ingenierie des matériaux

The biodegradable and biocompatible antibiotic containing thin film composites are very appropriate biomaterials as coating materials for dental implants because of their adjustable drug loading and release rates for the prevention of implant related infections. Coralline hydroxyapatite (HAp) was loaded with gentamicin antibiotics and combined with a biodegradable polylactic acid (PLA) to form thin film composites. PLA-HAp, PLA-Gentamicin (GM) and PLA-HAp-GM composites were produced, and their dissolution studies were carried out in phosphate buffered saline under SINK conditions. It was observed that the coatings could be efficiently applied to titanium dental implants and the drug release rates can be efficiently controlled.

Mots clés: Coating Dental Implants; Drug Release Studies; Hard Coral; Hydroxyapatite; PLA Thin Film Composites

Domaines: Matériaux; Sciences pharmaceutiques; Matériaux

Ipek Karacan, Innocent Jacob Macha, Gina Choi, Sophie Cazalbou, Besim Ben-Nissan. Antibiotic Containing Poly Lactic Acid/Hydroxyapatite Biocomposite Coatings for Dental Implant Applications. Key Engineering Materials, 2017, 758, pp.120-125. ⟨10.4028/www.scientific.net/KEM.758.120⟩. ⟨hal-02401568⟩