Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia

Emilie Eiselt , Simon Gonzalez (1) , Charlotte Martin (2) , Magali Chartier , Cecilia Betti , Jean-Michel Longpré , Florine Cavelier (3) , Dirk Tourwé (4) , Louis Gendron (5) , Steven Ballet , Philippe Sarret (6)

1 UCP - Université de Cergy Pontoise
2 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
3 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
4 Department of Organic Chemistry
5 Montreal Neurological Institute and Hospital
6 Department of Physiology and Biophysics

Domaines: Chimie thérapeutique

Emilie Eiselt, Simon Gonzalez, Charlotte Martin, Magali Chartier, Cecilia Betti, et al.. Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia. ACS Chemical Neuroscience, 2019, 10 (11), pp.4535-4544. ⟨10.1021/acschemneuro.9b00390⟩. ⟨hal-02400886⟩