γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor

Kyeongjin Kim , Ira Goldberg , Mark Graham , Meenakshi Sundaram , Enrico Bertaggia , Samuel Lee , Li Qiang , Rebecca Haeusler (1) , Daniel Metzger , Pierre Chambon (2) , Zemin Yao (3) , Henry Ginsberg (4) , Utpal Pajvani

1 Department of Pathology and Cell Biology [New York, NY, USA]
2 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
3 Department of Biochemistry, Microbiology and Immunology
4 Columbia University [New York]

Domaines: Organisation et fonctions cellulaires [q-bio.SC]

Kyeongjin Kim, Ira Goldberg, Mark Graham, Meenakshi Sundaram, Enrico Bertaggia, et al.. γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor. Cell Metabolism, 2018, 27 (4), pp.816-827.e4. ⟨10.1016/j.cmet.2018.02.010⟩. ⟨hal-02398228⟩