Intramolecular Photogeneration of a Tyrosine Radical in a Designed Protein

Alison G. Tebo , Annamaria Quaranta (1, 2) , Christian Herrero , Vincent L. Pecoraro , Ally Aukauloo (1, 2)

1 I2BC - Institut de Biologie Intégrative de la Cellule
2 LPB - Photocatalyse et Biohydrogène

Long-distance biological electron transfer occurs through a hopping mechanism and often involves tyrosine as a high potential intermediate, for example in the early charge separation steps during photosynthesis. Protein design allows for the development of minimal systems to study the underlying principles of complex systems. Herein, we report the development of the first ruthenium-linked designed protein for the photogeneration of a tyrosine radical by intramolecular electron transfer.

Mots clés: Electron transfer; Tyrosine; photochemistry; protein design; radicals

Domaines: Sciences du Vivant [q-bio]

Alison G. Tebo, Annamaria Quaranta, Christian Herrero, Vincent L. Pecoraro, Ally Aukauloo. Intramolecular Photogeneration of a Tyrosine Radical in a Designed Protein. ChemPhotoChem, 2017, 1 (3), pp.89--92. ⟨10.1002/cptc.201600044⟩. ⟨hal-02392036⟩