Nervous-Like Circuits in the Ribosome Facts, Hypotheses and Perspectives

Y. Timsit (1) , Daniel Bennequin (2)

1 MIO - Institut méditerranéen d'océanologie
2 IMJ - Institut de Mathématiques de Jussieu

In the past few decades, studies on translation have converged towards the metaphor of a "ribosome nanomachine"; they also revealed intriguing ribosome properties challenging this view. Many studies have shown that to perform an accurate protein synthesis in a fluctuating cellular environment, ribosomes sense, transfer information and even make decisions. This complex "behaviour" that goes far beyond the skills of a simple mechanical machine has suggested that the ribosomal protein networks could play a role equivalent to nervous circuits at a molecular scale to enable information transfer and processing during translation. We analyse here the significance of this analogy and establish a preliminary link between two fields: ribosome structure-function studies and the analysis of information processing systems. This cross-disciplinary analysis opens new perspectives about the mechanisms of information transfer and processing in ribosomes and may provide new conceptual frameworks for the understanding of the behaviours of unicellular organisms.

Mots clés: ribosome; neuron; network; translation; nervous circuit; information processing; evolution; complexity; protein interface

Domaines: Biochimie, Biologie Moléculaire; Biologie structurale [q-bio.BM]; Réseaux moléculaires [q-bio.MN]

Y. Timsit, Daniel Bennequin. Nervous-Like Circuits in the Ribosome Facts, Hypotheses and Perspectives. International Journal of Molecular Sciences, 2019, ⟨10.3390/ijms20122911⟩. ⟨hal-02390099⟩