A mobile loop near the active site acts as a switch between the dual activities of a viral protease/deubiquitinase

Isabelle Jupin , Maya Ayach (1) , Lucile Jomat , Sonia Fieulaine (1, 2) , Stéphane Bressanelli (1, 2)

1 I2BC - Institut de Biologie Intégrative de la Cellule
2 IMAPP - Interactions et mécanismes d’assemblage des protéines et des peptides

Mots clés: Animals; Chickens; Models; Molecular; Crystallography; X-Ray; Arabidopsis thaliana; Protein Conformation; Muramidase; Molecular Structure; Synchrotrons; Algorithms; Crystallization; crystal structure; Chemistry; Physical; crystals; Data Collection; Leaves; Microbial mutation; Molecular dynamics; Physicochemical Phenomena; Viral Replication

Domaines: Sciences du Vivant [q-bio]

Isabelle Jupin, Maya Ayach, Lucile Jomat, Sonia Fieulaine, Stéphane Bressanelli. A mobile loop near the active site acts as a switch between the dual activities of a viral protease/deubiquitinase. PLoS Pathogens, 2017, 13 (11), pp.e1006714. ⟨10.1371/journal.ppat.1006714⟩. ⟨hal-02389688⟩