Effects of Dexamethasone and Sulfasalazine on Prostaglandin E2 Output by Human Placental Cells In Vitro

Nasser Mirazi , Nadia Alfaidy (1) , Rebecca Martin , John Challis

1 BCI - Biologie du Cancer et de l'Infection

Prostaglandins (PG) are key mediators of the labor process. We investigated effects of dexamethasone on PGE2 output in term human placental cells in the presence of indomethacin, an inhibitor of PGH synthase enzymes PGHS1 and PGHS2 activity; meloxicam, a relatively specific inhibitor of PGHS2; and sulfasalazine, an inhibitor of 15-OH PG dehydrogenase (PGDH), a PG-metabolizing enzyme.

Domaines: Biologie de la reproduction

Nasser Mirazi, Nadia Alfaidy, Rebecca Martin, John Challis. Effects of Dexamethasone and Sulfasalazine on Prostaglandin E2 Output by Human Placental Cells In Vitro. Journal of the Society for Gynecologic Investigation, 2016, 11 (1), pp.22-26. ⟨10.1016/j.jsgi.2003.07.005⟩. ⟨hal-02385742⟩