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Synthesis and in Vitro Cytotoxic Evaluation of New Derivatives of Pyrido[1,2-a]benzimidazolic Ring System: The Pyrido[1,2:1,2]imidazo[4,5-h]quinazolines

Abstract : Access to the original series of pyrido[1',2':1,2]imidazo[4,5-h]quinazoline was developed from a 1,3-dicarbonyl unit with some “N-C-N” bisnucleophilic reagents and the derivatives obtained were evaluated for in vitro cytotoxic activities against HL60 and A2780 cells. All compounds exhibited cytotoxic activitise on resistant cell lines (MDR+; HL60R and A2780R) with no resistance phenomena.
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https://hal.archives-ouvertes.fr/hal-02384513
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Submitted on : Thursday, November 28, 2019 - 2:03:02 PM
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Marianne Dupuy, Frédéric Pinguet, Olivier Chavignon, Jean-Michel Chezal, Jean-Claude Teulade, et al.. Synthesis and in Vitro Cytotoxic Evaluation of New Derivatives of Pyrido[1,2-a]benzimidazolic Ring System: The Pyrido[1,2:1,2]imidazo[4,5-h]quinazolines. Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, 2001, 49, pp.1061 - 1065. ⟨10.1248/cpb.49.1061⟩. ⟨hal-02384513⟩

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