The remarkable UV light invulnerability of thymine GNA dinucleotides

Stéphanie Coantic-Castex (1) , Agathe Martinez (1) , Dominique Harakat (1) , Dominique Guillaume (1) , Pascale Clivio (1)

1 ICMR - Institut de Chimie Moléculaire de Reims - UMR 7312

We herein demonstrate the UV resistance of glycol nucleic acid (GNA) dinucleotides. This resistance sustains the hypothesis of GNA as a nucleic acid prebiotic ancestor on early Earth, a time of intense solar UV light. Such photorobustness, due to the absence of intrastrand base stacking, could offer an opportunity for nanodevice development requiring challenging UV conditions.

Domaines: Chimie organique

Stéphanie Coantic-Castex, Agathe Martinez, Dominique Harakat, Dominique Guillaume, Pascale Clivio. The remarkable UV light invulnerability of thymine GNA dinucleotides. Journal of the Chemical Society, Chemical Communications, 2019, 55, pp.12571-12574. ⟨10.1039/c9cc04355a⟩. ⟨hal-02380447⟩