Mitochondrial oxidative stress induces leaky ryanodine receptor during mechanical ventilation

Haikel Dridi (1, 2) , Mohamad Yehya (1) , Robert Barsotti (3) , Steven Reiken (4, 2) , Claire Angebault (1) , Boris Jung (5, 1) , Samir Jaber (1, 5) , Andrew Marks (2) , Alain Lacampagne (1) , Stefan Matecki (5, 1)

1 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
2 Columbia University College of Physicians and Surgeons
3 Department of Biomedical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA
4 Department of Physiology & Cellular Biophysics
5 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

Mots clés: Mitochondrial oxidative stress; Calcium homeostasis; Diaphragm contractile function

Domaines: Sciences du Vivant [q-bio]

Haikel Dridi, Mohamad Yehya, Robert Barsotti, Steven Reiken, Claire Angebault, et al.. Mitochondrial oxidative stress induces leaky ryanodine receptor during mechanical ventilation. Free Radical Biology and Medicine, 2020, ⟨10.1016/j.freeradbiomed.2019.11.019⟩. ⟨hal-02377213⟩