R. M. Lavker and T. T. Sun, Epidermal stem cells: properties, markers, and location, Proc Natl Acad Sci USA, vol.97, pp.13473-75, 2000.

A. Giangreco, S. J. Goldie, V. Failla, G. Saintigny, and F. M. Watt, Human skin aging is associated with reduced expression of the stem cell markers ?1 integrin and MCSP, J Invest Dermatol, vol.130, pp.604-612, 2010.

S. Chen, M. Lewallen, and T. Xie, Adhesion in the stem cell niche: biological roles and regulation, Development, vol.140, pp.255-65, 2013.

F. M. Watt, Epidermal stem cells: markers, patterning and the control of stem cell fate, Philos. Trans. R. Soc. B Biol, vol.353, pp.831-868, 1998.

E. C. Naylor, R. E. Watson, and M. J. Sherratt, Molecular aspects of skin ageing, Maturitas, vol.69, pp.249-56, 2011.

A. Ib, Signaling by reactive oxygen and nitrogen species in skin diseases, Curr Drug Metab, vol.11, pp.409-423, 2010.

J. Lu, A. Holmgren, and . Selenoproteins, J Biol Chem, vol.284, pp.723-750, 2009.

J. R. Arthur, The glutathione peroxidases, Cell Mol Life Sci, vol.57, pp.1825-1860, 2001.

T. S. Rafferty, R. C. Mckenzie, J. A. Hunter, A. F. Howie, J. R. Arthur et al., Differential expression of selenoproteins by human skin cells and protection by selenium from UVB-radiation-induced cell death, Biochem J, vol.332, pp.231-267, 1998.

M. T. Leccia, M. J. Richard, F. Joanny-crisci, and J. C. Beani, UV-A1 cytotoxicity and antioxidant defence in keratinocytes and fibroblasts, Eur J Dermatol, vol.8, pp.478-82, 1998.

M. S. Stewart, G. S. Cameron, and B. C. Pence, Antioxidant nutrients protect against UVB-induced oxidative damage to DNA of mouse keratinocytes in culture, J Invest Dermatol, vol.106, pp.1086-89, 1996.

A. Moysan, P. Morlière, I. Marquis, A. Richard, and L. Dubertret, Effects of selenium on UVA-induced lipid peroxidation in cultured human skin fibroblasts, Skin Pharmacol, vol.8, pp.139-187, 1995.

N. Emonet-piccardi, M. J. Richard, J. L. Ravanat, N. Signorini, J. Cadet et al., Protective effects of antioxidants against UVA-induced DNA damage in human skin fibroblasts in culture, Free Radic Res, vol.29, pp.307-320, 1998.

J. M. Bates, V. L. Spate, J. S. Morris, D. L. St-germain, and V. A. Galton, Effects of selenium deficiency on tissue selenium content, deiodinase activity, and thyroid hormone economy in the rat during development, Endocrinology, vol.141, pp.2490-500, 2000.

T. Kanekura, S. Yotsumoto, N. Maeno, A. Kamenosono, H. Saruwatari et al., Selenium deficiency: report of a case, Clin Exp Dermatol, vol.30, pp.346-394, 2005.

A. Sengupta, U. F. Lichti, B. A. Carlson, A. O. Ryscavage, V. N. Gladyshev et al., Selenoproteins are essential for proper keratinocyte function and skin development, PLoS One, vol.5, p.12249, 2010.

Y. Legrain, Z. Touat-hamici, and L. Chavatte, Interplay between selenium levels, selenoprotein expression, and replicative senescence in WI-38 human fibroblasts, J Biol Chem, vol.289, pp.6299-310, 2014.

R. T. Wu, L. Cao, B. P. Chen, and W. H. Cheng, Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation, J Biol Chem, vol.289, pp.34378-88, 2014.

N. T. Akbaraly, J. Arnaud, I. Hininger-favier, V. Gourlet, A. M. Roussel et al., Selenium and mortality in the elderly: results from the EVA study, Clin Chem, vol.51, pp.2117-2140, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00085045

A. L. Ray, R. D. Semba, J. Walston, L. Ferrucci, A. R. Cappola et al., Low serum selenium and total carotenoids predict mortality among older women living in the community: the women's health and aging studies, J Nutr, vol.136, pp.172-76, 2006.

C. Augustin, C. Collombel, and O. Damour, Use of Dermal Equivalent and Skin Equivalent Models for in Vitro Cutaneous Irritation Testing of Cosmetic Products: Comparison with in Vivo Human Data, J Toxicol Cutaneous Ocul Toxicol, vol.17, pp.5-17, 1998.

A. F. Black, C. Bouez, E. Perrier, K. Schlotmann, F. Chapuis et al., Optimization and characterization of an engineered human skin equivalent, Tissue Eng, vol.11, pp.723-756, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00313883

D. Santos, M. Metral, E. Boher, A. Rousselle, P. Thepot et al., In vitro 3-D model based on extending time of culture for studying chronological epidermis aging, Matrix Biol, vol.47, pp.85-97, 2015.

G. Cotsarelis, P. Kaur, D. Dhouailly, U. Hengge, and J. Bickenbach, Epithelial stem cells in the skin: definition, markers, localization and functions, Exp Dermatol, vol.8, pp.80-88, 1999.

A. Li, P. J. Simmons, and P. Kaur, Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype, Proc Natl Acad Sci USA, vol.95, pp.3902-3909, 1998.

P. H. Jones and F. M. Watt, Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression, Cell, vol.73, pp.713-737, 1993.

, , p.90251

F. M. Watt and P. H. Jones, Expression and function of the keratinocyte integrins, Dev Suppl, pp.185-92, 1993.

F. M. Watt and H. Fujiwara, Cell-extracellular matrix interactions in normal and diseased skin, Cold Spring Harb Perspect Biol, vol.3, p.5124, 2011.

A. Giangreco, M. Qin, J. E. Pintar, and F. M. Watt, Epidermal stem cells are retained in vivo throughout skin aging, Aging Cell, vol.7, pp.250-59, 2008.

J. Morgner, S. Ghatak, T. Jakobi, C. Dieterich, M. Aumailley et al., Integrin-linked kinase regulates the niche of quiescent epidermal stem cells, Nat Commun, vol.6, p.8198, 2015.

R. E. Burgeson and A. M. Christiano, The dermal-epidermal junction, Curr Opin Cell Biol, vol.9, pp.651-58, 1997.

R. F. Ghohestani, K. Li, P. Rousselle, and J. Uitto, Molecular organization of the cutaneous basement membrane zone, Clin Dermatol, vol.19, pp.551-62, 2001.
URL : https://hal.archives-ouvertes.fr/hal-00313092

, , pp.175-184

M. E. Waaijer, W. E. Parish, B. H. Strongitharm, D. Van-heemst, P. E. Slagboom et al., The number of p16INK4a positive cells in human skin reflects biological age, Aging Cell, vol.11, pp.722-747, 2012.

M. E. Waaijer, D. A. Gunn, P. D. Adams, J. S. Pawlikowski, C. E. Griffiths et al., P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age, J Gerontol A Biol Sci Med Sci, vol.71, pp.1022-1050, 2016.

S. Ressler, J. Bartkova, H. Niederegger, J. Bartek, K. Scharffetter-kochanek et al., p16INK4A is a robust in vivo biomarker of cellular aging in human skin, Aging Cell, vol.5, pp.379-89, 2006.

J. Adamus, S. Aho, H. Meldrum, C. Bosko, and J. M. Lee, p16INK4A influences the aging phenotype in the living skin equivalent, J Invest Dermatol, vol.134, pp.1131-1164, 2014.

B. Speckmann, S. Schulz, F. Hiller, D. Hesse, F. Schumacher et al., Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice, J Nutr Biochem, vol.48, pp.112-131, 2017.

N. Xiang, R. Zhao, G. Song, and W. Zhong, Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells, Carcinogenesis, vol.29, pp.2175-81, 2008.

H. Zeng, Selenite and selenomethionine promote HL-60 cell cycle progression, J Nutr, vol.132, pp.674-79, 2002.

A. Merlo, J. G. Herman, L. Mao, D. J. Lee, E. Gabrielson et al., 5? CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers, Nat Med, vol.1, pp.686-92, 1995.

E. Makrantonaki and C. C. Zouboulis, Molecular mechanisms of skin aging: state of the art, Ann N Y Acad Sci, vol.1119, pp.40-50, 2007.

Y. Barrandon and H. Green, Three clonal types of keratinocyte with different capacities for multiplication, Proc Natl Acad Sci USA, vol.84, pp.2302-2308, 1987.

T. Nishiyama, S. Amano, M. Tsunenaga, K. Kadoya, A. Takeda et al., The importance of laminin 5 in the dermal-epidermal basement membrane, J Dermatol Sci, vol.24, issue.1, pp.51-59, 2000.

P. Rousselle, G. P. Lunstrum, D. R. Keene, and R. E. Burgeson, Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments, J Cell Biol, vol.114, pp.567-76, 1991.
URL : https://hal.archives-ouvertes.fr/hal-00314053

S. Carulli, K. Beck, G. Dayan, S. Boulesteix, H. Lortat-jacob et al., Cell surface proteoglycans syndecan-1 and -4 bind overlapping but distinct sites in laminin ?3 LG45 protein domain, J Biol Chem, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00871195

, AGING, vol.287, pp.12204-12220

L. Shahabeddin, F. Berthod, O. Damour, and C. Collombel, Characterization of skin reconstructed on a chitosancross-linked collagen-glycosaminoglycan matrix, Skin Pharmacol, vol.3, pp.107-121, 1990.