Discovery of Imidazoquinazolinone Derivatives as TSPO Ligands Modulating Neurosteroidogenesis and Cellular Bioenergetics in Neuroblastoma Cells Expressing Amyloid Precursor Protein

François Hallé (1) , Imane Lejri (2) , Mustapha Abarghaz , Amandine Grimm (2) , Christian Klein , Michel Maitre (3) , Martine Schmitt (1) , Jean-Jacques Bourguignon (1) , Ayikoe Guy Mensah-Nyagan , Anne Eckert (4) , Frédéric Bihel (1)

1 LIT - Laboratoire d'Innovation Thérapeutique
2 BMNST - Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques
3 Physiopathologie du système nerveux.
4 Neurobiology Laboratory for Brain Aging and Mental Health

Domaines: Sciences du Vivant [q-bio]; Chimie

François Hallé, Imane Lejri, Mustapha Abarghaz, Amandine Grimm, Christian Klein, et al.. Discovery of Imidazoquinazolinone Derivatives as TSPO Ligands Modulating Neurosteroidogenesis and Cellular Bioenergetics in Neuroblastoma Cells Expressing Amyloid Precursor Protein. ChemistrySelect, 2017, 2 (22), pp.6452-6457. ⟨10.1002/slct.201701565⟩. ⟨hal-02368811⟩