Ribosome Evolution and Structural Capacitance

Ashley M Buckle , Malcolm Buckle (1)

1 LBPA - Laboratoire de Biologie et de Pharmacologie Appliquée

In addition to the canonical loss-of-function mutations, mutations in proteins may additionally result in gain-of-function through the binary activation of cryptic "structural capacitance elements." Our previous bioinformatic analysis allowed us to propose a new mechanism of protein evolution-structural capacitance-that arises via the generation of new elements of microstructure upon mutations that cause a disorder-to-order (D→O) transition in previously disordered regions of proteins. Here we propose that the D→O transition is a necessary follow-on from expected early codon-anticodon and tRNA acceptor stem-amino acid usage, via the accumulation of structural capacitance elements-reservoirs of disorder in proteins. We develop this argument further to posit that structural capacitance is an inherent consequence of the evolution of the genetic code.

Mots clés: structural capacitance; disorder-order transition; ribosome evolution; protein disordered region; genetic code; codon-anticodon

Domaines: Sciences du Vivant [q-bio]; Biochimie, Biologie Moléculaire; Biologie moléculaire

Ashley M Buckle, Malcolm Buckle. Ribosome Evolution and Structural Capacitance. Frontiers in Molecular Biosciences, 2019, 6, ⟨10.3389/fmolb.2019.00123⟩. ⟨hal-02368285⟩