Bridging the Gap between Brain-Derived Neurotrophic Factor and Glucocorticoid Effects on Brain Networks

Freddy Jeanneteau (1) , Amélie Borie (1) , Moses Chao (2) , Michael J Garabedian

1 IGF - Institut de Génomique Fonctionnelle
2 NKI - Nathan S. Kline Institute for Psychiatric Research

Behavioral choices made by the brain during stress depend on glucocorticoid and brain-derived neurotrophic factor (BDNF) signaling pathways acting in synchrony in the meso-limbic (reward) and corticolimbic (emotion) neural networks. Deregulated expression of BDNF and glucocorticoid receptors in brain valuation areas may compromise the integration of signals. Glucocorticoid receptor phosphorylation upon BDNF signaling in neurons represents one mechanism underlying the integration of BDNF and glucocorticoid signals that when off balance may lay the foundation of malad-aptations to stress. Here, we propose that BDNF signaling conditions glucocorticoid responses impacting neural plasticity in the mesocorticolimbic system. This provides a novel molecular framework for understanding how brain networks use BDNF and glucocorticoid signaling contingencies to forge receptive neuronal fields in temporal domains defined by behavioral experience, and in mood disorders.

Domaines: Neurosciences [q-bio.NC]

Freddy Jeanneteau, Amélie Borie, Moses Chao, Michael J Garabedian. Bridging the Gap between Brain-Derived Neurotrophic Factor and Glucocorticoid Effects on Brain Networks. Neuroendocrinology, 2018, ⟨10.1159/000496392⟩. ⟨hal-02368008⟩