Intramolecular Imino Diels−Alder Reaction: Progress toward the Synthesis of Uncialamycin

Abstract : We herein described an intramolecular imino Diels−Alder reaction promoted with BF3·OEt2/DDQ affording substituted quinolines. Using this procedure, we prepared the chiral quinoline moiety of the uncialamycin, a new enediyne natural product.
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https://hal.archives-ouvertes.fr/hal-02355118
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Submitted on : Friday, November 8, 2019 - 10:01:40 AM
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Sandy Desrat, Pierre van de Weghe. Intramolecular Imino Diels−Alder Reaction: Progress toward the Synthesis of Uncialamycin. Journal of Organic Chemistry, American Chemical Society, 2009, 74 (17), pp.6728-6734. ⟨10.1021/jo901291t⟩. ⟨hal-02355118⟩

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