Septin functions during neuro-development, a yeast perspective

Septin functions during neuro-development, a yeast perspective.

Julien Falk (1, 2) , Leila Boubakar , Valérie Castellani (1, 2)

1 CGPhiMC - Centre de génétique et de physiologie moléculaire et cellulaire
2 INMG - Institut NeuroMyoGène

Septins, discovered almost half a century ago in yeast, have prominent contributions in a broad range of morphological and functional processes from yeast to human. Septins now emerge as key players of neurodevelopment and more specifically of the mechanisms driving the complex morphological differentiation and compartmentalization of neurons that are fundamental to their function. We review here recent advances in Septin-mediated processes of neuron differentiation, which enlighten similarities and differences between neuron and yeast polarity programs.

Domaines: Sciences du Vivant [q-bio]; Neurobiologie; Biologie du développement

Julien Falk, Leila Boubakar, Valérie Castellani. Septin functions during neuro-development, a yeast perspective. Current Opinion in Neurobiology, 2019, 57, pp.102-109. ⟨10.1016/j.conb.2019.01.012⟩. ⟨hal-02354482⟩