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Journal articles
Interleukin‐18 produced by bone marrow‐derived stromal cells supports T ‐cell acute leukaemia progression
Benjamin Uzan
1
Sandrine Poglio
1
Bastien Gerby
1
Ching‐lien Wu
1
Julia Gross
1
Florence Armstrong
1
Julien Calvo
1
Xavier Cahu
1
Caroline Deswarte
2
Florent Dumont
3
Diana Passaro
4
Corinne Besnard‐guérin
Thierry Leblanc
5
Andre Baruchel
6
Judith Landman‐parker
Paola Ballerini
4, 1
Véronique Baud
3
Jacques Ghysdael
4
Frederic Baleydier
7
Francoise Porteu
8
Francoise Pflumio
1
Benjamin Uzan 1
Author
Sandrine Poglio 1
Author
Bastien Gerby 1
Author IdHAL : bastien-gerby ORCID : https://orcid.org/0000-0002-2657-4200
Ching‐lien Wu 1
Author
Caroline Deswarte 2
Author
Florent Dumont 3
Author
Diana Passaro 4
Author
Corinne Besnard‐guérin
Author
Thierry Leblanc 5
Author
Andre Baruchel 6
Author
Judith Landman‐parker
Author
Paola Ballerini 4, 1
Author
Véronique Baud 3
Author
Jacques Ghysdael 4
Author
Frederic Baleydier 7
Author
Francoise Porteu 8
Author
Francoise Pflumio 1
Author
1
IRCM - Institut de Radiobiologie Cellulaire et Moléculaire (France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : DRF/IRCM (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- Université Paris-Saclay (Espace Technologique, Bat. Discovery - RD 128 - 2e ét., 91190 Saint-Aubin - France)
2
INPT - EI Purpan - Ecole d'Ingénieurs de Purpan (France)
- Toulouse INP - Institut National Polytechnique (Toulouse) (France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
3
IC UM3 (UMR 8104 / U1016) - Institut Cochin (22 rue Méchain, 75014 Paris - France)
- UPD5 - Université Paris Descartes - Paris 5 : UM 3 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1016 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 8104 (France)
4
Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau] (26, avenue du Docteur Arnold-Netter 75571 PARIS Cedex 12 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Trousseau [APHP] (26 Avenue du Dr Arnold Netter, 75012 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Sorbonne Université (France)
5
JPL - Jet Propulsion Laboratory (4800 Oak Grove Drive, Pasadena, CA 91109-8099, USA - United States)
- CALTECH - California Institute of Technology (1200 East California Blvd, Pasadena, California 91125 - United States)
- NASA (www.nasa.gov - United States)
6
Service d'hématologie pédiatrique (Paris - France)
- Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris] (200 rue du Faubourg Saint-Denis 75475 Paris (Nord) Cedex 10 - France)
- UPD7 - Université Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
7
UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon (28, rue Laennec - 69373 Lyon - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1052 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5286 (France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- Centre Léon Bérard [Lyon] (28, rue Laennec 69373 LYON Cedex 08 - France)
8
U1170 Inserm - Hématopoïèse normale et pathologique (Gustave Roussy - Pavillon de recherche 1 - 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- IGR - Institut Gustave Roussy (114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1170 (101, rue de Tolbiac, 75013 Paris - France)
Abstract : Development of novel therapies is critical for T-cell acute leukaemia (T-ALL). Here, we investigated the effect of inhibiting the MAPK/MEK/ERK pathway on TALL cell growth. Unexpectedly, MEK inhibitors (MEKi) enhanced growth of 70% of human TALL cell samples cultured on stromal cells independently of NOTCH activation and maintained their ability to propagate in vivo. Similar results were obtained when TALL cells were cultured with ERK1/ 2-knockdown stromal cells or with conditioned medium from MEKi-treated stromal cells. Microarray analysis identified interleu-kin 18 (IL-18) as transcriptionally up-regulated in MEKi-treated MS5 cells. Recombinant IL-18 promoted TALL growth in vitro, whereas the loss of function of IL-18 receptor in TALL blast cells decreased blast proliferation in vitro and in NSG mice. The NFKB pathway that is downstream to IL-18R was activated by IL-18 in blast cells. IL-18 circulating levels were increased in TALL -xeno-grafted mice and also in TALL patients in comparison with controls. This study uncovers a novel role of the pro-inflammatory cytokine IL-18 and outlines the microenvironment involvement in human TALL development.
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Journal articles
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https://hal.archives-ouvertes.fr/hal-02353722
Contributor : Bastien Gerby <>
Submitted on : Wednesday, May 6, 2020 - 7:05:20 PM
Last modification on : Thursday, December 10, 2020 - 3:38:33 AM
Contributor : Bastien Gerby <>
Submitted on : Wednesday, May 6, 2020 - 7:05:20 PM
Last modification on : Thursday, December 10, 2020 - 3:38:33 AM
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Interleukin-18 produced by bon...
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Identifiers
- HAL Id : hal-02353722, version 1
- DOI : 10.1002/emmm.201303286
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USPC | SORBONNE-UNIVERSITE | CRCL | UNIV-PARIS | UP-SANTE | IGR | FNCLCC | CEA | UNIV-PARIS5 | UNIV-PARIS7 | UPMC | CNRS | UNIV-LYON1 | UDL | JACOB | CEA-DRF | SU-MEDECINE | SU-TI
Citation
Benjamin Uzan, Sandrine Poglio, Bastien Gerby, Ching‐lien Wu, Julia Gross, et al.. Interleukin‐18 produced by bone marrow‐derived stromal cells supports T ‐cell acute leukaemia progression. EMBO Molecular Medicine, Wiley Open Access, 2014, 6 (6), pp.821-834. ⟨10.1002/emmm.201303286⟩. ⟨hal-02353722⟩
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