, Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia, Nat. Genet, vol.42, pp.530-535, 2010.

E. Klumper, R. Pieters, A. J. Veerman, D. R. Huismans, A. H. Loonen et al., In vitro cellular drug resistance in children with relapsed/refractory acute lymphoblastic leukemia, Blood, vol.86, pp.3861-3868, 1995.

C. G. Mullighan, L. A. Phillips, X. Su, J. Ma, C. B. Miller et al., Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia, Science, vol.322, pp.1377-1380, 2008.

T. Palomero, W. K. Lim, D. T. Odom, M. L. Sulis, P. J. Real et al., NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth, Proc. Natl. Acad. Sci. USA, vol.103, pp.18261-18266, 2006.

T. Palomero, M. L. Sulis, M. Cortina, P. J. Real, K. Barnes et al., Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia, Nat. Med, vol.13, pp.1203-1210, 2007.

C. H. Pui, L. L. Robison, and A. T. Look, Acute lymphoblastic leukaemia, Lancet, vol.371, pp.1030-1043, 2008.

P. J. Real, V. Tosello, T. Palomero, M. Castillo, E. Hernando et al., Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia, Nat. Med, vol.15, pp.50-58, 2009.

M. Shackleton, E. Quintana, E. R. Fearon, and S. J. Morrison, Heterogeneity in cancer: cancer stem cells versus clonal evolution, Cell, vol.138, pp.822-829, 2009.

S. K. Singh, C. Hawkins, I. D. Clarke, J. A. Squire, J. Bayani et al., Identification of human brain tumour initiating cells, Nature, vol.432, pp.396-401, 2004.

J. Soulier, E. Clappier, J. M. Cayuela, A. Regnault, M. García-peydró et al., HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL), Blood, vol.106, pp.274-286, 2005.

F. J. Staal, D. De-ridder, T. Szczepanski, T. Schonewille, E. C. Van-der-linden et al., , 2010.

, Genome-wide expression analysis of paired diagnosis-relapse samples in ALL indicates involvement of pathways related to DNA replication, cell cycle and DNA repair, independent of immune phenotype, Leukemia, vol.24, pp.491-499

V. Tosello, M. R. Mansour, K. Barnes, M. Paganin, M. L. Sulis et al., WT1 mutations in T-ALL, vol.114, pp.1038-1045, 2009.

P. Van-vlierberghe, R. Pieters, H. B. Beverloo, and J. P. Meijerink, Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia, Br. J. Haematol, vol.143, pp.153-168, 2008.

A. P. Weng, A. A. Ferrando, W. Lee, J. P. Morris, I. V. et al., Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia, Science, vol.306, pp.269-271, 2004.

J. J. Yang, D. Bhojwani, W. Yang, X. Cai, G. Stocco et al., Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia, Blood, vol.112, pp.4178-4183, 2008.

O. H. Yilmaz, R. Valdez, B. K. Theisen, W. Guo, D. O. Ferguson et al., Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells, Nature, vol.441, pp.475-482, 2006.

J. Zuna, A. M. Ford, M. Peham, N. Patel, V. Saha et al., TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia, Clin. Cancer Res, vol.10, pp.5355-5360, 2004.

I. Aifantis, E. Raetz, and S. Buonamici, Molecular pathogenesis of T-cell leukaemia and lymphoma, Nat. Rev. Immunol, vol.8, pp.380-390, 2008.

K. Anderson, C. Lutz, F. W. Van-delft, C. M. Bateman, Y. Guo et al., Genetic variegation of clonal architecture and propagating cells in leukaemia, Nature, vol.469, pp.356-361, 2011.

F. Armstrong, P. Brunet-de-la-grange, B. Gerby, M. C. Rouyez, J. Calvo et al., NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity, Blood, vol.113, pp.1730-1740, 2009.
URL : https://hal.archives-ouvertes.fr/hal-02353664

L. C. Bailey, B. J. Lange, S. R. Rheingold, and N. J. Bunin, Bonemarrow relapse in paediatric acute lymphoblastic leukaemia, Lancet Oncol, vol.9, pp.873-883, 2008.

D. Bhojwani, H. Kang, N. P. Moskowitz, D. J. Min, H. Lee et al., Biologic pathways associated with relapse in childhood acute lymphoblastic leukemia: a Children's Oncology Group study, Blood, vol.108, pp.711-717, 2006.

A. D. Boiko, O. V. Razorenova, M. Van-de-rijn, S. M. Swetter, D. L. Johnson et al., Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271, Nature, vol.466, pp.133-137, 2010.

S. Choi, M. J. Henderson, E. Kwan, A. H. Beesley, R. Sutton et al., Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subclone, Blood, vol.110, pp.632-639, 2007.

E. Clappier, W. Cuccuini, A. Kalota, A. Crinquette, J. M. Cayuela et al., The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children, Blood, vol.110, pp.1251-1261, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00165499

K. De-keersmaecker, P. Marynen, and J. Cools, Genetic insights in the pathogenesis of T-cell acute lymphoblastic leukemia, Haematologica, vol.90, pp.1116-1127, 2005.

J. E. Dick, Stem cell concepts renew cancer research, Blood, vol.112, pp.4793-4807, 2008.

A. A. Ferrando, D. S. Neuberg, J. Staunton, M. L. Loh, C. Huard et al., Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia, Cancer Cell, vol.1, pp.18-19, 2002.

D. R. Freyer, M. Devidas, M. La, W. L. Carroll, P. S. Gaynon et al., Postrelapse survival in childhood acute lymphoblastic leukemia is independent of initial treatment intensity: a report from the Children's Oncology Group, Blood, vol.117, pp.3010-3015, 2011.

B. Gerby, F. Armstrong, P. B. De-la-grange, H. Medyouf, J. Calvo et al., Optimized gene transfer into human primary leukemic T cell with NOD-SCID/ leukemia-initiating cell activity, Leukemia, vol.24, pp.646-649, 2010.
URL : https://hal.archives-ouvertes.fr/hal-02353660

A. Gutierrez, T. Sanda, R. Grebliunaite, A. Carracedo, L. Salmena et al., High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia, Blood, vol.114, pp.647-650, 2009.

R. Kirschner-schwabe, C. Lottaz, J. Tödling, P. Rhein, L. Karawajew et al., Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia, Clin. Cancer Res, vol.12, pp.4553-4561, 2006.

M. Kleppe, I. Lahortiga, T. E. Chaar, K. De-keersmaecker, N. Mentens et al.,