Therapeutic approaches to bone diseases, Science, vol.289, pp.1508-1514, 2000. ,
Osteocyte mechanobiology and pericellular mechanics, Annu. Rev. Biomed. Eng, vol.12, pp.369-400, 2010. ,
New insights into osteoclastogenic signaling mechanisms, Trends Endocrinol. Metab, vol.23, pp.582-590, 2012. ,
Central control of bone formation, J. Bone Miner. Metab, vol.19, pp.195-198, 2001. ,
,
Estrogen prevents bone loss via estrogen receptor ? and induction of Fas ligand in osteoclasts, Cell, vol.130, pp.811-823, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00188977
Autotaxin and LPA receptor signaling in cancer, Cancer Metastasis Rev, vol.30, pp.557-565, 2011. ,
Lysophosphatidic acid and calcitriol co-operate to promote human osteoblastogenesis: requirement of albumin-bound LPA, Prostaglandins Other Lipid Mediat, vol.95, pp.45-52, 2011. ,
Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival, J. Biol. Chem, vol.285, pp.25792-25801, 2010. ,
Lysophosphatidic acid induces osteocyte dendrite outgrowth, Biochem. Biophys. Res. Commun, vol.357, pp.194-199, 2007. ,
Development of our current understanding of bioactive lysophospholipids, Ann. N.Y. Acad. Sci, vol.905, pp.1-10, 2000. ,
The bioactive phospholipid lysophosphatidic acid is released from activated platelets, Biochem. J, vol.291, pp.677-680, 1993. ,
Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer, J. Clin. Invest, vol.114, pp.1714-1725, 2004. ,
URL : https://hal.archives-ouvertes.fr/inserm-00110127
P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis, J. Cell Biol, vol.181, pp.859-871, 2008. ,
LPA receptors: subtypes and biological actions, Annu. Rev. Pharmacol. Toxicol, vol.50, pp.157-186, 2010. ,
Insights into the pharmacological relevance of lysophospholipid receptors, Br. J. Pharmacol, vol.165, pp.829-844, 2012. ,
Lysophosphatidic acid (LPA) and its receptors, Curr. Opin. Pharmacol, vol.9, pp.15-23, 2009. ,
Lysophosphatidic acidinduced expression of periostin in stromal cells: Prognostic relevance of periostin expression in epithelial ovarian cancer, Int. J. Cancer, vol.128, pp.332-342, 2010. ,
Lysophosphatidic acid: A potential mediator of osteoblastosteoclast signaling in bone, Biochim. Biophys. Acta, vol.1831, pp.109-116, 2013. ,
Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior, Proc. Natl. Acad. Sci. U.S.A, vol.97, pp.13384-13389, 2000. ,
Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex, J. Cell Biol, vol.135, pp.1071-1083, 1996. ,
Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding, Nat. Neurosci, vol.6, pp.1292-1299, 2003. ,
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling, Nat. Med, vol.10, pp.712-718, 2004. ,
Lysophosphatidic acid signaling may initiate fetal hydrocephalus, Sci. Transl. Med, vol.3, pp.99-87, 2011. ,
The lysophosphatidic acid receptor LPA(1) links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak, 2008. ,
, , vol.14, pp.45-54
Lysophosphatidic acid stimulates the intestinal brush border Na ? /H ? exchanger 3 and fluid absorption via LPA(5) and NHERF2, Gastroenterology, vol.138, pp.649-658, 2010. ,
Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure, Circ. Res, vol.103, pp.662-670, 2008. ,
Altered food consumption in mice lacking lysophosphatidic acid receptor-1, J. Physiol. Biochem, vol.65, pp.345-350, 2009. ,
Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass, Bone, vol.49, pp.395-403, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00615224
Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2), Mol. Cell. Biol, vol.22, pp.6921-6929, 2002. ,
LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing, Nature, vol.435, pp.104-108, 2005. ,
Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling, Biol. Reprod, vol.79, pp.328-336, 2008. ,
regulates blood and lymphatic vessel formation during mouse embryogenesis, Blood, vol.116, pp.5060-5070, 2010. ,
LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4, J. Cell. Biochem, vol.109, pp.794-800, 2010. ,
Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain, J. Biol. Chem, vol.287, pp.17608-17617, 2012. ,
Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid, J. Biol. Chem, vol.273, pp.7906-7910, 1998. ,
Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist, Mol. Pharmacol, vol.60, pp.1173-1180, 2001. ,
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors, Mol. Pharmacol, vol.64, pp.994-1005, 2003. ,
Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis, Int. J. Oncol, vol.40, pp.1133-1141, 2012. ,
GPR92 as a new G 12/13 -and G q -coupled lysophosphatidic acid receptor that increases cAMP, LPA5, J. Biol. Chem, vol.281, pp.23589-23597, 2006. ,
Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6, J. Biol. Chem, vol.284, pp.17731-17741, 2009. ,
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion, Mol. Cell. Biol, vol.20, pp.4106-4114, 2000. ,
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis, Nature, vol.458, pp.524-528, 2009. ,
Analyzing real-time PCR data by the comparative C(T) method, Nat. Protoc, vol.3, pp.1101-1108, 2008. ,
Genetic regulation of osteoclast development and function, Nat. Rev. Genet, vol.4, pp.638-649, 2003. ,
G-protein-coupled receptor expression, function, and signaling in macrophages, J. Leukocyte Biol, vol.82, pp.16-32, 2007. ,
Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate, Cell. Signal, vol.15, pp.367-375, 2003. ,
Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages, Biochim. Biophys. Acta, vol.1682, pp.112-119, 2004. ,
Podosome and sealing zone: specificity of the osteoclast model, Eur. J. Cell Biol, vol.85, pp.195-202, 2006. ,
Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contraction, Mol. Biol. Cell, vol.8, pp.1415-1425, 1997. ,
The ovariectomized rat model of postmenopausal bone loss, Bone Miner, vol.15, pp.175-191, 1991. ,
Secreted tartrate-resistant acid phosphatase 5b is a marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model, Calcif. Tissue Int, vol.82, pp.108-115, 2008. ,
Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts, PLoS ONE, vol.5, p.9741, 2010. ,
2010) c-Src-mediated phosphorylation of thyroid hormone receptor-interacting protein 6 (TRIP6) promotes osteoclast sealing zone formation, J. Biol. Chem, vol.285, pp.26641-26651 ,
Rho GTPases in osteoclasts: orchestrators of podosome arrangement, Eur. J. Cell Biol, vol.87, pp.469-477, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-02323478
A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid, Proc. Natl. Acad. Sci. U.S.A, vol.95, pp.6151-6156, 1998. ,
Lysophosphatidic acid: G-protein signalling and cellular responses, Curr. Opin. Cell Biol, vol.9, pp.168-173, 1997. ,
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells, J. Natl. Cancer Inst, vol.100, pp.1630-1642, 2008. ,
Mitogenic action of LPA in prostate, Biochim. Biophys. Acta, vol.1582, pp.265-269, 2002. ,
Bioactive lipids lysophosphatidic acid and sphingosine 1-phosphate mediate breast cancer cell biological functions through distinct mechanisms, Oncol. Res, vol.18, pp.173-184, 2009. ,
LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation, vol.27, pp.1830-1846, 2013. ,
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems, Nat. Rev. Immunol, vol.7, pp.292-304, 2007. ,
) c-Fms and the ?v?3 integrin collaborate during osteoclast differentiation, J. Clin. Invest, vol.111, pp.749-758, 2003. ,
Expression of the SRF gene occurs through a Ras/Sp/SRF-mediated-mechanism in response to serum growth signals, Oncogene, vol.18, pp.7319-7327, 1999. ,
Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance, Prostaglandins Other Lipid Mediat, vol.91, pp.130-138, 2010. ,
Pleiotropic activity of lysophosphatidic acid in bone metastasis, Biochim. Biophys. Acta, vol.1831, pp.99-104, 2013. ,
Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37), Biochem. Biophys. Res. Commun, vol.267, pp.213-220, 2000. ,
Parathyroid hormone-related protein: an update, J. Clin. Endocrinol. Metab, vol.97, pp.2947-2956, 2012. ,
The anabolic effect of human PTH(1-34) on bone formation is blunted when bone resorption is inhibited by the bisphosphonate tiludronate-is activated resorption a prerequisite for the in vivo effect of PTH on formation in a remodeling system, Bone, vol.16, pp.603-610, 1995. ,
Bone response to intermittent parathyroid hormone is altered in mice null for ?-arrestin2, Endocrinology, vol.146, pp.1854-1862, 2005. ,
Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: an analysis by DNA microarray, J. Cell. Biochem, vol.95, pp.403-418, 2005. ,
The use of bisphosphonates in cancer treatment, Ann. N.Y. Acad. Sci, vol.1218, pp.3-14, 2011. ,
The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases, Proc. Natl. Acad. Sci. U.S.A, vol.103, pp.9643-9648, 2006. ,
New insights into the molecular mechanisms of action of bisphosphonates, Curr. Pharm. Des, vol.9, pp.2643-2658, 2003. ,
Lysophosphatidic acid cooperates with 1?,25(OH)2D3 in stimulating human MG63 osteoblast maturation, Prostaglandins Other Lipid Mediat, vol.80, pp.46-61, 2006. ,
Necessity of lysophosphatidic acid receptor 1 for development of arthritis, Arthritis Rheum, vol.65, pp.2037-2047, 2013. ,