H. Esmail, C. E. Barry, Y. Db, and R. J. Wilkinson, The ongoing challenge of latent tuberculosis, Philos Trans R Soc Lond B Biol Sci, vol.369, 2014.

R. Houben and P. J. Dodd, The global burden of latent tuberculosis infection: A re-estimation using mathematical modelling, PLoS Med, vol.13, p.1002152, 2016.

, Global tuberculosis report, WHO, 2018.

M. W. Borgdorff, The incubation period distribution of tuberculosis estimated with a molecular epidemiological approach, Int J Epidemiol, vol.40, pp.964-970, 2011.

R. Puffer, Familial Susceptibility to Tuberculosis: Its Importance as a Public Health Problem, 1944.

L. Abel, Genetics of human susceptibility to active and latent tuberculosis: Present knowledge and future perspectives, Lancet Infect Dis, vol.18, pp.64-75, 2018.

F. J. Kallmann and D. Reisner, Twin studies on the significance of genetic factors in tuberculosis, Am Rev Tuberc, vol.47, pp.549-571, 1943.

F. Von-verschuer, Twin research from the time of Francis Galton to the presentday, Proc R Soc Lond B Biol Sci, vol.128, pp.62-81, 1939.

K. Pearson, Discussion on the influence of heredity on disease, with special reference to tuberculosis, cancer, and diseases of the nervous system: Introductory address, Proc R Soc Med, vol.2, pp.54-60, 1909.

F. Altare, Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency, Science, vol.280, pp.1432-1435, 1998.

F. Altare, Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection, J Clin Invest, vol.102, pp.2035-2040, 1998.

R. De-jong, Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients, Science, vol.280, pp.1435-1438, 1998.

E. Jouanguy, Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection, N Engl J Med, vol.335, pp.1956-1961, 1996.

M. J. Newport, A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection, N Engl J Med, vol.335, pp.1941-1949, 1996.

J. Bustamante, S. Boisson-dupuis, A. L. Casanova, and J. , Mendelian susceptibility to mycobacterial disease: Genetic, immunological, and clinical features of inborn errors of IFN-? immunity, Semin Immunol, vol.26, pp.454-470, 2014.

S. Dupuis, Human interferon-gamma-mediated immunity is a genetically controlled continuous trait that determines the outcome of mycobacterial invasion, Immunol Rev, vol.178, pp.129-137, 2000.

F. Altare, Interleukin-12 receptor beta1 deficiency in a patient with abdominal tuberculosis, J Infect Dis, vol.184, pp.231-236, 2001.

S. Boisson-dupuis, IL-12R?1 deficiency in two of fifty children with severe tuberculosis from Iran, Morocco, and Turkey, PLoS One, vol.6, p.18524, 2011.

S. Boisson-dupuis, Inherited and acquired immunodeficiencies underlying tuberculosis in childhood, Immunol Rev, vol.264, pp.103-120, 2015.

I. Caragol, Clinical tuberculosis in 2 of 3 siblings with interleukin-12 receptor beta1 deficiency, Clin Infect Dis, vol.37, pp.302-306, 2003.

A. Y. Kreins, Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome, J Exp Med, vol.212, pp.1641-1662, 2015.

N. Ozbek, Interleukin-12 receptor beta 1 chain deficiency in a child with disseminated tuberculosis, Clin Infect Dis, vol.40, pp.55-58, 2005.

P. Tabarsi, Lethal tuberculosis in a previously healthy adult with IL-12 receptor deficiency, J Clin Immunol, vol.31, pp.537-539, 2011.

S. Boisson-dupuis, Tuberculosis and impaired IL-23-dependent IFN-? immunity in humans homozygous for a common TYK2 missense variant, Sci Immunol, vol.3, p.8714, 2018.
URL : https://hal.archives-ouvertes.fr/pasteur-02070591

C. A. Dendrou, Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity, Sci Transl Med, vol.8, pp.363-149, 2016.

R. Martínez-barricarte, Human IFN-? immunity to mycobacteria is governed by both IL-12 and IL-23, Sci Immunol, vol.3, p.6759, 2018.

C. Bycroft, The UK Biobank resource with deep phenotyping and genomic data, Nature, vol.562, pp.203-209, 2018.

A. Belkadi, Whole-exome sequencing to analyze population structure, parental inbreeding, and familial linkage, Proc Natl Acad Sci, vol.113, pp.6713-6718, 2016.

R. Woodfield and C. L. Sudlow,

, Accuracy of patient self-report of stroke: A systematic review from the UK Biobank stroke outcomes group, PLoS One, vol.10, p.137538, 2015.

P. Glaziou, K. Floyd, and M. Raviglione, Trends in tuberculosis in the UK, Thorax, vol.73, pp.702-703, 2018.

P. Khanna, V. Nikolayevskyy, F. Warburton, E. Dobson, and F. Drobniewski, Rate of latent tuberculosis infection detected by occupational health screening of nurses new to a London teaching hospital, Infect Control Hosp Epidemiol, vol.30, pp.581-584, 2009.

B. J. Gray, S. E. Perrett, B. Gudgeon, and A. G. Shankar, Investigating the prevalence of latent Tuberculosis infection in a UK remand prison, J Public Health, 2019.

P. Health-england, Tuberculosis in England. Available at, 2017.

H. Schurz, A sex-stratified genome-wide association study of tuberculosis using a multi-ethnic genotyping array, Front Genet, vol.9, p.678, 2019.

R. Zheng, Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese, Nat Commun, vol.9, p.4072, 2018.

H. Qi, Discovery of susceptibility loci associated with tuberculosis in Han Chinese, Hum Mol Genet, vol.26, pp.4752-4763, 2017.

R. S. Sobota, A locus at 5q33.3 confers resistance to tuberculosis in highly susceptible individuals, Am J Hum Genet, vol.98, pp.514-524, 2016.

G. Sveinbjornsson, HLA class II sequence variants influence tuberculosis risk in populations of European ancestry, Nat Genet, vol.48, pp.318-322, 2016.

A. V. Grant, A genome-wide association study of pulmonary tuberculosis in Morocco, Hum Genet, vol.135, pp.299-307, 2016.

J. Curtis, Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration, Nat Genet, vol.47, pp.523-527, 2015.

E. R. Chimusa, Genome-wide association study of ancestry-specific TB risk in the South African coloured population, Hum Mol Genet, vol.23, pp.796-809, 2014.

S. Mahasirimongkol, Genome-wide association studies of tuberculosis in Asians identify distinct at-risk locus for young tuberculosis, J Hum Genet, vol.57, pp.363-367, 2012.

E. Png, A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians, BMC Med Genet, vol.13, p.5, 2012.

T. Thye, Common variants at 11p13 are associated with susceptibility to tuberculosis, Nat Genet, vol.44, pp.257-259, 2012.

T. Thye, African TB Genetics Consortium; Wellcome Trust Case Control Consortium (2010) Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11, Nat Genet, vol.42, issue.2, pp.739-741

Y. Luo, Progression of recent Mycobacterium tuberculosis exposure to active tuberculosis is a highly heritable complex trait driven by 3q23 in Peruvians, 2018.

O. Canela-xandri, K. Rawlik, and A. Tenesa, An atlas of genetic associations in UK Biobank, Nat Genet, vol.50, pp.1593-1599, 2018.

D. Diogo, TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on nonautoimmune complex traits, PLoS One, vol.10, p.122271, 2015.

A. Cortes, International Genetics of Ankylosing Spondylitis Consortium

. Australo-anglo, TASC

, Groupe Française d'Etude Génétique des Spondylarthrites (GFEGS)

, Spondyloarthritis Research Consortium of Canada (SPARCC

, Wellcome Trust Case Control Consortium 2 (WTCCC2) (2013) Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci, Nat Genet, vol.45, pp.730-738

A. H. Beecham, International Multiple Sclerosis Genetics Consortium (IMSGC

, Wellcome Trust Case Control Consortium 2 (WTCCC2); International IBD Genetics Consortium (IIBDGC) (2013) Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis, Nat Genet, vol.45, pp.1353-1360

L. Jostins, International IBD Genetics Consortium (IIBDGC) (2012) Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease, Nature, vol.491, pp.119-124

L. C. Tsoi, Collaborative Association Study of Psoriasis

, Genetic Analysis of Psoriasis Consortium; Psoriasis Association Genetics Extension; Wellcome Trust Case Control Consortium 2 (2012) Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity, Nat Genet, vol.44, pp.1341-1348

N. Fodil, D. Langlais, and P. Gros, Primary immunodeficiencies and inflammatory disease: A growing genetic intersection, Trends Immunol, vol.37, pp.126-140, 2016.

D. Langlais, N. Fodil, and P. Gros, Genetics of infectious and inflammatory diseases: Overlapping discoveries from association and exome-sequencing studies, Annu Rev Immunol, vol.35, pp.1-30, 2017.

M. Gadina, Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs, J Leukoc Biol, vol.104, pp.499-514, 2018.

X. He, X. Chen, H. Zhang, T. Xie, and X. Ye, Selective Tyk2 inhibitors as potential therapeutic agents: A patent review, Expert Opin Ther Pat, vol.29, pp.137-149, 2015.

K. Papp, Phase 2 trial of selective tyrosine kinase 2 inhibition in psoriasis, N Engl J Med, vol.379, pp.1313-1321, 2018.

F. O. Kaya, Anti-TNF treatment and tuberculosis, Austin J Pulm Respir Med, vol.4, p.1055, 2017.

R. J. Dubos and J. Dubos, The White Plague: Tuberculosis, Man, and Society, 1987.

J. F. Murray, The Industrial Revolution and the decline in death rates from tuberculosis, Int J Tuberc Lung Dis, vol.19, pp.502-503, 2015.

I. Olalde, The Beaker phenomenon and the genomic transformation of northwest Europe, Nature, vol.555, pp.190-196, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02006656

C. Fieschi, Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor ?1 deficiency: Medical and immunological implications, J Exp Med, vol.197, pp.527-535, 2003.

S. M. Holland, Immunotherapy of mycobacterial infections, Semin Respir Infect, vol.16, pp.47-59, 2001.

Z. F. Udwadia, R. A. Amale, K. K. Ajbani, and C. Rodrigues, Totally drug-resistant tuberculosis in India, Clin Infect Dis, vol.54, pp.579-581, 2012.

C. L. Daley and J. A. Caminero, Management of multidrug-resistant tuberculosis, Semin Respir Crit Care Med, vol.39, pp.310-324, 2018.

K. Dheda, The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis, Lancet Respir Med, issue.17, pp.30079-30085, 2017.

J. Casanova, Human genetic basis of interindividual variability in the course of infection, Proc Natl Acad Sci, vol.112, pp.7118-7127, 2015.

J. Casanova, Severe infectious diseases of childhood as monogenic inborn errors of immunity, Proc Natl Acad Sci, vol.112, pp.7128-7137, 2015.

J. C. Cohen and H. H. Hobbs, Simple genetics for a complex disease, Genetics, vol.340, pp.689-690, 2013.

A. Chakravarti, A. G. Clark, and V. K. Mootha, Distilling pathophysiology from complex disease genetics, Cell, vol.155, pp.21-26, 2013.

J. C. Florez, J. Hirschhorn, and D. Altshuler, The inherited basis of diabetes mellitus: Implications for the genetic analysis of complex traits, Annu Rev Genomics Hum Genet, vol.4, pp.257-291, 2003.

N. Katsanis, The continuum of causality in human genetic disorders, Genome Biol, vol.17, p.233, 2016.

P. J. Mclaren and M. Carrington, The impact of host genetic variation on infection with HIV-1, Nat Immunol, vol.16, pp.577-583, 2015.

J. Mcclellan and M. King, Genetic heterogeneity in human disease, Cell, vol.141, pp.210-217, 2010.

J. Casanova and L. Abel, Genetic dissection of immunity to mycobacteria: The human model, Annu Rev Immunol, vol.20, pp.581-620, 2002.

R. P. Lifton, Genetic dissection of human blood pressure variation: Common pathways from rare phenotypes, Harvey Lect, vol.100, pp.71-101, 2004.