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S. Figure and P. , A) P2 (age 46) presented with disseminated flat, reddish, and white pityriasis versicolor-like lesions on the trunk, hyperkeratotic warts on the hand, and seborrheic keratosis-like lesions the forehead. (B) P15 (age 58) presented with disseminated flat, reddish, white pityriasis versicolor-like lesions on the hands, knees, and neck. (C) P19 (age 12) presented with disseminated flat, pityriasis versicolor-like lesions all over the head, arms, and trunk. See Table S1 for more information. (D) P23 (age 22) and P20 (age 47), her father, presented reddish, hyperkeratotic lesions on the face, arms, and trunk that had developed in early childhood

S. Figure, Unique bands were excised and subjected to mass spectrometry. The hits obtained were pooled and stringently filtered against the CRAPome database. The top 10 hits in terms of total number of peptides detected are presented. MW, molecular weight. (B) RNA was isolated from untreated HEK293T cells and reverse transcribed. EVER1 and EVER2 mRNA levels were determined by RT-qPCR. Each bar represents three independent measurement per gene of interest. The data were normalized against two different housekeeping genes: GAP DH and RNaseP. Error bars represent SD. (C) Gene ontology PAN THER overrepresentation test. We ran 244 CIB1 interactors identified in A against the Reactome (version 58; released 2016-12-07) database containing 21,042 genes. Bonferroni correction for multiple testing was applied. Fold enrichment and P values <0.05 are displayed. (D) Visual representation of B. The size of each cloud corresponds to the fold enrichment for the pathway indicated. P values are indicated within each cloud. (E) Primary keratinocytes were transfected with plasmids encoding CIB1-HA and ZnT1-Flag alone or in combination. 1 d after transfection, cells were subjected to immunofluorescence imaging with Alexa Fluor 568-HA and Alexa Fluor 488-FLAG antibody combinations. DAPI was used for counterstaining, Mass spectrometry analysis and CIB1-ZnT1 colocalization. (A) HEK293T cells were transfected with a plasmid encoding CIB1-FLAG. After 36 h, cells were lysed in RIPA buffer and subjected to immunoprecipitation with FLAG-Ezview resin for 4 h. Proteins were separated on 4-12% Bis-Tris gels, which were then stained with colloidal Coomassie blue solution overnight

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S. Gazal, M. Sahbatou, M. Babron, E. Génin, and A. L. Leutenegger, FSuite: exploiting inbreeding in dense SNP chip and exome data, Bioinforma, vol.30, pp.1940-1941, 2014.
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