The type II secretion system – a dynamic fiber assembly nanomachine

Abstract : Type II secretion systems (T2SSs) share common origins and structure with archaeal flagella (archaella) and pili, bacterial competence systems and type IV pili. All of these systems use a conserved ATP-powered machinery to assemble helical fibers that are anchored in the plasma membrane. The T2SSs assemble pseudopili, periplasmic filaments that promote extracellular secretion of folded periplasmic proteins. Comparative analysis of T2SSs and related fiber assembly nanomachines might provide important clues on their functional specificities and dynamics. This review focuses on recent developments in the study of pseudopilus structure and biogenesis, and discusses mechanistic models of pseudopilus function in protein secretion.
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Submitted on : Wednesday, November 6, 2019 - 3:24:25 PM
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M. Nilges, Manuel Campos, David Cisneros, Mangayarkarasi Nivaskumar, Olivera Francetic. The type II secretion system – a dynamic fiber assembly nanomachine. Research in Microbiology, Elsevier, 2013, 164 (6), pp.545-555. ⟨10.1016/j.resmic.2013.03.013⟩. ⟨hal-02351800⟩

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