Imino-tetrahydro-benzothiazole Derivatives as p53 Inhibitors: Discovery of a Highly Potent in Vivo Inhibitor and Its Action Mechanism

Nicolas Pietrancosta (1, 2) , Anice Moumen (3) , Rosanna Dono (4) , Paul Lingor , Veronique Planchamp , Fabienne Lamballe (4) , Mathias Bähr (5) , Jean-Louis Kraus (6) , Flavio Maina (4)

1 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
2 LBM UMR 7203 - Laboratoire des biomolécules
3 The Mediterranean Institute of Neurobiology
4 IBDM - Institut de Biologie du Développement de Marseille
5 UMG - University Medical Center Göttingen
6 Rétrovirus et Maladies Associées

Domaines: Chimie thérapeutique

Nicolas Pietrancosta, Anice Moumen, Rosanna Dono, Paul Lingor, Veronique Planchamp, et al.. Imino-tetrahydro-benzothiazole Derivatives as p53 Inhibitors: Discovery of a Highly Potent in Vivo Inhibitor and Its Action Mechanism. Journal of Medicinal Chemistry, 2006, 49 (12), pp.3645-3652. ⟨10.1021/jm060318n⟩. ⟨hal-02351704⟩