A serine/threonine kinase gene defective in Peutz?Jeghers syndrome, Nature, vol.391, issue.6663, pp.184-187, 1998. ,
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade, J Biol, vol.2, issue.4, p.28, 2003. ,
LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade, Current Biology, vol.13, issue.22, pp.2004-2008, 2003. ,
URL : https://hal.archives-ouvertes.fr/inserm-00390855
AMP-activated Protein Kinase Activity Is Critical for Hypoxia-inducible Factor-1 Transcriptional Activity and Its Target Gene Expression under Hypoxic Conditions in DU145 Cells, Journal of Biological Chemistry, vol.278, issue.41, pp.39653-39661, 2003. ,
AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling, Journal of Biological Chemistry, vol.277, issue.27, pp.23977-23980, 2002. ,
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival, Cell Metabolism, vol.23, issue.4, pp.649-662, 2016. ,
mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome, Proceedings of the National Academy of Sciences, vol.106, issue.27, pp.11137-11142, 2009. ,
Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1, Proceedings of the National Academy of Sciences, vol.111, issue.7, pp.2554-2559, 2014. ,
PGC-1?, SIRT1 and AMPK, an energy sensing network that controls energy expenditure, Current Opinion in Lipidology, vol.20, issue.2, pp.98-105, 2009. ,
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity, Nature, vol.458, issue.7241, pp.1056-1060, 2009. ,
Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle, Journal of Applied Physiology, vol.88, issue.6, pp.2219-2226, 2000. ,
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress, Proceedings of the National Academy of Sciences, vol.101, issue.10, pp.3329-3335, 2004. ,
Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase, Nature Genetics, vol.18, issue.1, pp.38-43, 1998. ,
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung, Cancer Res, vol.62, issue.13, pp.3659-62, 2002. ,
Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells, Cancer Genetics and Cytogenetics, vol.197, issue.2, pp.130-141, 2010. ,
Lkb1 Deficiency Causes Prostate Neoplasia in the Mouse, Cancer Research, vol.68, issue.7, pp.2223-2232, 2008. ,
Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation, Hepatology, vol.49, issue.2, pp.608-617, 2008. ,
LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration, Cell Reports, vol.22, issue.8, pp.1994-2005, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-02349915
Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer, Oncotarget, vol.6, issue.4, pp.2509-2523, 2014. ,
Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress, Molecular Cell, vol.57, issue.6, pp.1022-1033, 2015. ,
LKB1 and AMP-activated protein kinase: regulators of cell polarity, Genes Cells, vol.17, issue.9, pp.737-784, 2012. ,
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome, Biochem J, vol.362, issue.2, pp.481-90, 2002. ,
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD, EMBO J, vol.22, issue.12, pp.3062-72, 2003. ,
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm, EMBO J, vol.22, issue.19, pp.5102-5116, 2003. ,
STRAD? Regulates LKB1 Localization by Blocking Access to Importin-?, and by Association with Crm1 and Exportin-7, Molecular Biology of the Cell, vol.19, issue.4, pp.1614-1626, 2008. ,
STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice, J Clin Invest, vol.120, issue.5, pp.1591-602, 2010. ,
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK, Nature Chemical Biology, vol.8, issue.11, pp.897-904, 2012. ,
Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity, Biochem J, vol.458, issue.1, pp.41-56, 2014. ,
A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress, Cell Reports, vol.12, issue.5, pp.734-742, 2015. ,
Hypoxia Inactivates the VHL Tumor Suppressor through PIASy-Mediated SUMO Modification, PLoS ONE, vol.5, issue.3, p.e9720, 2010. ,
PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells, Journal of Cell Science, vol.126, issue.17, pp.3939-3947, 2013. ,
RSUME, a Small RWD-Containing Protein, Enhances SUMO Conjugation and Stabilizes HIF-1? during Hypoxia, Cell, vol.131, issue.2, pp.309-323, 2007. ,
Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis, Journal of Biological Chemistry, vol.285, issue.47, pp.36682-36688, 2010. ,
Deciphering the emerging role of SUMO conjugation in the hypoxia-signaling cascade, Biol Chem, vol.394, issue.4, pp.459-69, 2013. ,
Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma, Journal of Gastroenterology and Hepatology, vol.22, issue.8, pp.1178-1182, 2007. ,
Hypoxia inducible factor in hepatocellular carcinoma: A therapeutic target, World Journal of Gastroenterology, vol.21, issue.42, p.12171, 2015. ,
SUMO and the robustness of cancer, Nature Reviews Cancer, vol.17, issue.3, pp.184-197, 2017. ,
S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers, Hepatology, vol.56, issue.3, pp.982-993, 2012. ,
Cbx4 Governs HIF-1? to Potentiate Angiogenesis of Hepatocellular Carcinoma by Its SUMO E3 Ligase Activity, Cancer Cell, vol.25, issue.1, pp.118-131, 2014. ,
Neoangiogenesis-related genes are hallmarks of fast-growing hepatocellular carcinomas and worst survival. Results from a prospective study, Gut, vol.65, issue.5, pp.861-869, 2015. ,
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation, Hepatology, vol.55, issue.4, pp.1237-1248, 2012. ,
SUMO-1 modification activates the transcriptional response of p53, The EMBO Journal, vol.18, issue.22, pp.6455-6461, 1999. ,
Analysis of SUMOylated proteins using SUMO-traps, Scientific Reports, vol.3, issue.1, p.1690, 2013. ,
Protein Structure Modeling with MODELLER, Methods in Molecular Biology, vol.426, pp.145-159, 2008. ,
The Amber biomolecular simulation programs, Journal of Computational Chemistry, vol.26, issue.16, pp.1668-1688, 2005. ,
ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB, Journal of Chemical Theory and Computation, vol.11, issue.8, pp.3696-3713, 2015. ,
Structural Role of RKS Motifs in Chromatin Interactions: A Molecular Dynamics Study of HP1 Bound to a Variably Modified Histone Tail, Biophysical Journal, vol.102, issue.8, pp.1926-1933, 2012. ,
Interaction Models for Water in Relation to Protein Hydration, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, pp.331-342, 1981. ,
Molecular dynamics with coupling to an external bath, The Journal of Chemical Physics, vol.81, issue.8, pp.3684-3690, 1984. ,
PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data, Journal of Chemical Theory and Computation, vol.9, issue.7, pp.3084-3095, 2013. ,
UCSF Chimera?A visualization system for exploratory research and analysis, Journal of Computational Chemistry, vol.25, issue.13, pp.1605-1612, 2004. ,
Hepatoma cells from mice deficient in glycine Nmethyltransferase have increased RAS signaling and activation of liver kinase B1, Gastroenterology, vol.143, issue.3, pp.1-13, 2012. ,
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis, Hepatology, vol.52, issue.5, pp.1621-1631, 2010. ,
HuR/Methyl-HuR and AUF1 Regulate the MAT Expressed During Liver Proliferation, Differentiation, and Carcinogenesis, Gastroenterology, vol.138, issue.5, pp.1943-1953.e3, 2010. ,
SUMO and Its Role in Human Diseases, International Review of Cell and Molecular Biology, vol.288, pp.167-183, 2011. ,
Strategies to Identify Recognition Signals and Targets of SUMOylation, Biochemistry Research International, vol.2012, pp.1-16, 2012. ,
SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies, Scientific Reports, vol.6, issue.1, p.26509, 2016. ,
Sumo-1 Function Is Dispensable in Normal Mouse Development, Molecular and Cellular Biology, vol.28, issue.17, pp.5381-5390, 2008. ,
SENP2 regulated the stability of ?-catenin through WWOX in hepatocellular carcinoma cell, Tumor Biology, vol.35, issue.10, pp.9677-9682, 2014. ,
JASSA: a comprehensive tool for prediction of SUMOylation sites and SIMs, Bioinformatics, vol.31, issue.21, pp.3483-3491, 2015. ,
SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1, Journal of Biological Chemistry, vol.283, issue.41, pp.27628-27635, 2008. ,
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism, Proceedings of the National Academy of Sciences, vol.110, issue.30, pp.E2772-E2781, 2013. ,
Structure of the complex of phosphorylated liver kinase B1 and 14-3-3zeta, Acta Crystallogr F Struct Biol Commun, vol.73, pp.196-201, 2017. ,
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice, Hepatology, vol.47, issue.4, pp.1191-1200, 2008. ,
Hypoxia-induced angiogenesis: good and evil, Genes Cancer, vol.2, issue.12, pp.1117-1150, 2011. ,
Genetic analysis of the LKB1/ STK11 gene in hepatocellular carcinomas, Eur J Cancer, vol.40, issue.1, pp.136-177, 2004. ,
Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1, Oncogene, vol.4, p.168, 2015. ,
Loss of LKB1 and p53 synergizes to alter fallopian tube epithelial phenotype and high-grade serous tumorigenesis, Oncogene, vol.35, issue.1, pp.59-68, 2016. ,
Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3, Oncogene, vol.36, issue.41, pp.5709-5730, 2017. ,
LKB1 is necessary for Aktmediated phosphorylation of proapoptotic proteins, Cancer Res, vol.68, issue.18, pp.7270-7277, 2008. ,
Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells, J Biol Chem, vol.281, issue.10, pp.6366-75, 2006. ,
URL : https://hal.archives-ouvertes.fr/inserm-00390882
Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMPactivated protein kinase in endothelial cells, Circulation, vol.117, issue.7, pp.952-62, 2008. ,
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation, Mol Cell, vol.33, issue.2, pp.237-284, 2009. ,
In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy, Mol Cell Proteomics, vol.7, issue.1, pp.132-176, 2008. ,
Regulation and function of SUMO modification, J Biol Chem, vol.279, issue.52, pp.53899-902, 2004. ,
STE20-related kinase adaptor protein alpha (STRADalpha) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells, J Biol Chem, vol.287, issue.22, pp.18758-68, 2012. ,
LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation, Cancer Res, vol.66, issue.22, pp.10701-10709, 2006. ,
Wild-type function of the p53 tumor suppressor protein is not required for apoptosis of mouse hepatoma cells, Cell Death Differ, vol.5, issue.1, pp.87-95, 1998. ,
Function of RasGRP3 in the formation and progression of human breast cancer, Mol Cancer, vol.13, p.96, 2014. ,
ATP and MO25? Regulate the Conformational State of the STRAD? Pseudokinase and Activation of the LKB1 Tumour Suppressor, PLoS Biology, vol.7, issue.6, p.e1000126, 2009. ,