C. H. Pui, W. L. Carroll, S. Meshinchi, and R. J. Arceci, Biology, risk stratification, and therapy of pediatric acute leukemias: An update, J Clin Oncol, vol.29, pp.551-565, 2011.

S. A. Armstrong and A. T. Look, Molecular genetics of acute lymphoblastic leukemia, J Clin Oncol, vol.23, pp.6306-6315, 2005.

R. R. Hardy, B-cell commitment, development and selection, Immunol Rev, vol.175, pp.23-32, 2000.

B. Adams, Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis, Genes Dev, vol.6, pp.1589-1607, 1992.

P. Urbánek, Z. Q. Wang, I. Fetka, E. F. Wagner, and M. Busslinger, Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP, Cell, vol.79, pp.901-912, 1994.

A. Souabni, C. Cobaleda, M. Schebesta, and M. Busslinger, Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1, Immunity, vol.17, pp.781-793, 2002.

K. P. Nera, Loss of Pax5 promotes plasma cell differentiation, Immunity, vol.24, pp.283-293, 2006.

S. L. Nutt, B. Heavey, A. G. Rolink, and M. Busslinger, Pillars article: Commitment to the Blymphoid lineage depends on the transcription factor Pax5, J Immunol, vol.401, pp.766-772, 1999.

K. Nebral, Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia, Leukemia, vol.23, pp.134-143, 2009.

J. Familiades, PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: A GRAALL study, Leukemia, vol.23, pp.1989-1998, 2009.

C. G. Mullighan, Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia, Nature, vol.446, pp.758-764, 2007.

J. Medvedovic, A. Ebert, H. Tagoh, and M. Busslinger, Pax5: A master regulator of B cell development and leukemogenesis, Adv Immunol, vol.111, pp.179-206, 2011.

M. Bousquet, A novel PAX5-ELN fusion protein identified in B-cell acute lymphoblastic leukemia acts as a dominant negative on wild-type PAX5, Blood, vol.109, pp.3417-3423, 2007.

E. Coyaud, Wide diversity of PAX5 alterations in B-ALL: A Groupe Francophone de Cytogenetique Hematologique study, Blood, vol.115, pp.3089-3097, 2010.

L. Smeenk, Molecular role of the PAX5-ETV6 oncoprotein in promoting Bcell acute lymphoblastic leukemia, EMBO J, vol.36, pp.718-735, 2017.

S. Kurahashi, PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML, Oncogene, vol.30, pp.1822-1830, 2011.

N. Kawamata, M. A. Pennella, J. L. Woo, A. J. Berk, and H. P. Koeffler, Dominant-negative mechanism of leukemogenic PAX5 fusions, Oncogene, vol.31, pp.966-977, 2012.

D. J. Kemp, A. W. Harris, C. S. Adams, and J. M. , Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines, Proc Natl Acad Sci, vol.77, pp.2876-2880, 1980.

D. Haddad, Sense transcription through the S region is essential for immunoglobulin class switch recombination, EMBO J, vol.30, pp.1608-1620, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00591921

D. Jung, C. Giallourakis, R. Mostoslavsky, and F. W. Alt, Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus, Annu Rev Immunol, vol.24, pp.541-570, 2006.

F. Z. Braikia, G. Chemin, M. Moutahir, and A. A. Khamlichi, Quantification of V(D)J recombination by real-time quantitative PCR, Immunol Lett, vol.162, pp.119-123, 2014.

-. Revilla and R. , The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis, EMBO J, vol.31, pp.3130-3146, 2012.

S. L. Nutt, B. Heavey, A. G. Rolink, and M. Busslinger, Commitment to the B-lymphoid lineage depends on the transcription factor Pax5, Nature, vol.401, pp.556-562, 1999.

J. Dang, PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia, Blood, vol.125, pp.3609-3617, 2015.

L. M. Heltemes-harris, Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia, J Exp Med, vol.208, pp.1135-1149, 2011.

G. Cazzaniga, The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case, Cancer Res, vol.61, pp.4666-4670, 2001.

G. Fazio, PAX5/ETV6 alters the gene expression profile of precursor B cells with opposite dominant effect on endogenous PAX5, Leukemia, vol.27, pp.992-995, 2013.

A. Souabni, W. Jochum, and M. Busslinger, Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus, Blood, vol.109, pp.281-289, 2007.

L. Van-der-weyden, Somatic drivers of B-ALL in a model of, pp.6-7, 2015.

. Pax5, BMC Cancer, vol.15, p.585

J. Duque-afonso, Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia, J Clin Invest, vol.125, pp.3667-3680, 2015.

C. G. Mullighan, JAK mutations in high-risk childhood acute lymphoblastic leukemia, Proc Natl Acad Sci, vol.106, pp.9414-9418, 2009.

D. Denk, J. Bradtke, M. König, and S. Strehl, PAX5 fusion genes in t(7;9)(q11.2;p13) leukemia: A case report and review of the literature, Mol Cytogenet, vol.7, p.13, 2014.

D. Hong, Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia, Science, vol.319, pp.336-339, 2008.

B. Gerby, SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells, PLoS Genet, vol.10, p.1004768, 2014.
URL : https://hal.archives-ouvertes.fr/hal-02353324

A. V. Krivtsov, Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9, Nature, vol.442, pp.818-822, 2006.

L. I. Shlush, Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia, HALT Pan-Leukemia Gene Panel Consortium, vol.506, p.420, 2014.

C. G. Mullighan, Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia, Science, vol.322, pp.1377-1380, 2008.