Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells

Abstract : Patients with T-cell immunodeficiencies are generally treated with allogeneic hematopoietic stem cell transplantation, but alternatives are needed for patients without matched donors. An innovative intrathymic gene therapy approach that directly targets the thymus might improve outcomes.
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https://hal.archives-ouvertes.fr/hal-02350097
Contributor : Valerie Zimmermann <>
Submitted on : Tuesday, November 5, 2019 - 10:32:35 PM
Last modification on : Thursday, November 7, 2019 - 1:28:21 AM

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Marie Pouzolles, Alice Machado, Mickaël Guilbaud, Magali Irla, Sarah Gailhac, et al.. Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells. Journal of Allergy and Clinical Immunology, Elsevier, 2019, ⟨10.1016/j.jaci.2019.08.029⟩. ⟨hal-02350097⟩

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