G. Klein, The approaching era of the tumor suppressor genes, Science, vol.238, pp.1539-1545, 1987.

T. Takahashi, Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions, Cancer Res, vol.52, pp.230-2343, 1992.

D. W. Cai, Stable expression of the wild-type p53 gene in human lung cancer cells after retrovirus-mediated gene transfer, Hum Gene Ther, vol.4, pp.617-624, 1993.

S. J. Baker, Suppression of human colorectal carcinoma cell growth by wild-type p53, Science, vol.249, pp.912-915, 1990.

T. Takahashi, p53: a frequent target for genetic abnormalities in lung cancer, Science, vol.246, pp.491-494, 1989.

M. Favrot, J. L. Coll, N. Louis, and A. Negoescu, Cell death and cancer: replacement of apoptotic genes and inactivation of death suppressor genes in therapy, Gene Therapy, vol.5, pp.728-739, 1998.

T. Fujiwara, Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model, J Natl Cancer Inst, vol.86, pp.1458-1462, 1994.

K. N. Wills, Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer, Hum Gene Ther, vol.5, pp.1079-1088, 1994.

J. L. Coll, Antitumoral activity of bax and p53 gene transfer in lung cancer: in vitro and in vivo analysis, Hum Gene Ther, vol.9, pp.2063-2074, 1998.

K. Hamada, Adenovirus-mediated transfer of a wild-type p53 gene and induction of apoptosis in cervical cancer, Cancer Res, vol.56, pp.3047-3054, 1996.

H. Symonds, P53-dependent apoptosis suppresses tumor growth and progression in vivo, Cell, vol.78, pp.703-711, 1994.

K. M. Dameron, Control of angiogenesis in fibroblast by p53 regulation of thrombospondin-1, Science, vol.265, pp.1582-1584, 1994.

A. Kistner, Doxycycline-mediated quantitative and tissuespecific control of gene expression in transgenic mice, Proc Natl Acad Sci, vol.93, pp.10933-10938, 1996.

L. Dubrez, Caffeine sensitizes human H358 cell line to p53-mediated apoptosis by inducing mitochondria translocation and conformational change of BAX protein, J Biol Chem, vol.276, pp.38980-38987, 2001.

Z. Y. Yang, The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo, Nat Med, vol.1, pp.1052-1056, 1995.

D. Michalovitz, O. Halevy, and M. Oren, Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53, Cell, vol.62, pp.671-680, 1990.

X. Chen, L. J. Ko, L. Jayaraman, and C. Prives, p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells, Genes Dev, vol.10, pp.2438-2451, 1996.

Q. M. Chen, J. Liu, and J. B. Merrett, Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and BAX in H2O2 response of normal human fibroblasts, Biochem J, vol.347, pp.543-551, 2000.

T. Mukhopadhyay and J. A. Roth, Superinduction of wild-type p53 protein after 2-methoxyestradiol treatment of Ad5p53-transduced cells induces tumor cell apoptosis, Oncogene, vol.17, pp.241-246, 1998.

. Craig, Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells, Oncogene, vol.16, pp.265-272, 1998.

R. Alemany, Growth inhibitory effect of anti-K-ras adenovirus on lung cancer cells, Cancer Gene Ther, vol.3, pp.296-301, 1996.

A. S. Lundberg, W. C. Hahn, P. Gupta, and R. A. Weinberg, Genes involved in senescence and immortalization, Curr Opin Cell Biol, vol.12, pp.705-709, 2000.

M. M. Sugrue, Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53, Proc Natl Acad Sci, vol.94, pp.9468-9653, 1997.

D. Xu, Down-regulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells, Oncogene, vol.19, pp.5123-5133, 2000.

T. Kanaya, Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription, Clin Cancer Res, vol.6, pp.1239-1247, 2000.

C. J. Jones, Evidence for a telomere-independent 'clock' limiting RAS oncogene-driven proliferation of human thyroid epithelial cells, Mol Cell Biol, vol.20, pp.5690-5699, 2000.

S. Wei and J. M. Sedivy, Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts, Cancer Res, vol.59, pp.1539-1543, 1999.

L. Holmgren, G. Jackson, and J. Arbiser, p53 induces angiogenesisrestricted dormancy in a mouse fibrosarcoma, Oncogene, vol.17, pp.819-824, 1998.

T. Riccioni, Adenovirus-mediated wild-type p53 overexpression inhibits endothelial cell differentiation in vitro and angiogenesis in vivo, Gene Therapy, vol.5, pp.747-754, 1998.

. Smith, Replicative senescence: implications for in vivo aging and tumor suppression, Science, vol.273, pp.63-67, 1996.

A. Negoescu, In situ apoptotic cell labeling by the TUNEL method improvement and evolution on cell preparations, J Histochem Cytochem, vol.44, pp.959-968, 1996.

G. P. Dimri, A biomarker that identifies senescent human cells in culture and in aging skin in vivo, Proc Natl Acad Sci, vol.92, pp.9363-9367, 1995.