Cell cycle arrest is sufficient for p53-mediated tumor regression

Abstract : p53 gene therapy can induce tumor regression, but the low efficacy of in vivo gene transfer has greatly hampered the mechanistic analysis of this antitumoral activity. We therefore used a p53-null human NSCLC cell line in which we reintroduced the wild-type p53 gene under control of a tetra-cycline-dependent promoter. P53 induction provokes cell cycle arrest in G 0 /G 1 and G 2 /M phase, an up-regulation of p21, a down-regulation of cyclin B1 and appearance of sen-escence features without down-regulation of human telomer-ase reverse transcriptase. No detectable morphological
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  • HAL Id : hal-02349477, version 1

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L Dubrez, J-L Coll, A Hurbin, F de Fraipont, S Lantejoul, et al.. Cell cycle arrest is sufficient for p53-mediated tumor regression. Gene Therapy, Nature Publishing Group, 2001, 8, pp.1705 - 1712. ⟨hal-02349477⟩

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