Synthesis and Structure–Activity Relationship Studies of Benzo[ b ][1,4]oxazin‐3(4 H )‐one Analogues as Inhibitors of Mycobacterial Thymidylate Synthase X

Jakub Modranka , Jiahong Li (1) , Anastasia Parchina , Michiel Vanmeert , Shrinivas Dumbre , Mayla Salman , Hannu Myllykallio (2) , Hubert Becker , Roeland Vanhoutte , Lia Margamuljana (3) , Hoai Viet Nguyen (4) , Rania Abu el‐asrar , Jef Rozenski (5) , Piet Herdewijn (6) , Steven De jonghe , Eveline Lescrinier (5)

1 Northeast Agricultural University Heilongjiang
2 LOB - Laboratoire d'Optique et Biosciences
3 Rega Institute for Medical Research [Leuven, België]
4 Cologne University of Applied Sciences
5 Laboratory for Medicinal Chemistry
6 Laboratory for Medicinal Chemistry, Rega Institute for Medical Research

Domaines: Biochimie, Biologie Moléculaire; Biochimie [q-bio.BM]; Chimie thérapeutique

Jakub Modranka, Jiahong Li, Anastasia Parchina, Michiel Vanmeert, Shrinivas Dumbre, et al.. Synthesis and Structure–Activity Relationship Studies of Benzo[ b ][1,4]oxazin‐3(4 H )‐one Analogues as Inhibitors of Mycobacterial Thymidylate Synthase X. ChemMedChem, 2019, 14 (6), pp.645-662. ⟨10.1002/cmdc.201800739⟩. ⟨hal-02347378⟩