Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus

Camille Dumon (1) , Lucie Pisella (1) , Diabe Diabira (1) , Yasmine Belaidouni (1) , Gary Wayman (2) , Jean-Luc Gaïarsa (1)

1 INMED - INSERM U1249 - Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université]
2 WSU - Washington State University

The adipose-derived circulating hormone leptin plays a pivotal role in the control of energy balance and body weight. Sound data indicate that this hormone also acts as an important developmental signal impacting a number of brain regions during fetal and postnatal stages. Leptin levels surge during the two first postnatal weeks of life in rodents. This period is characterized by the presence of early network driven activity in the immature hippocampus, the so-called Giant Depolarizing Potentials (GDPs). GDPs are thought to contribute to the wiring of the hippocampal network. We therefore tested the effect of leptin on GDPs. Leptin increased GDPs frequency between the postnatal days (P) 1 and 3 via a calcium/Calmodulin-dependent kinase (CaMK) and extracellular signal-related kinase (ERK) dependent pathways. Between P6 and P7, leptin inhibited the frequency of GDPs through the activation of large conductance Ca 2+ activated K + (BK) channels driven by a phosphoinositol-3 kinase (PI3K) dependent pathway. These results show that leptin exerts a bi-directional and age-dependent control of GDPs and extends the scope of leptin's action in the developing brain.

Mots clés: GDPs; leptin; CaMK; ERK; BK-channels; PI3K; immature networks

Domaines: Neurobiologie; Endocrinologie et métabolisme; Biologie du développement

Camille Dumon, Lucie Pisella, Diabe Diabira, Yasmine Belaidouni, Gary Wayman, et al.. Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus. Frontiers in Cellular Neuroscience, 2019, 13, pp.254. ⟨10.3389/fncel.2019.00254⟩. ⟨hal-02346946⟩