B. Dehay, Targeting ?-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations, Lancet Neurol, vol.14, issue.8, pp.855-866, 2015.

R. Yan, Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB, Proc Natl Acad Sci USA, vol.115, issue.51, pp.12053-12062, 2018.

M. Bourdenx, E. Bezard, and B. Dehay, Lysosomes and ?-synuclein form a dangerous duet leading to neuronal cell death, Front Neuroanat, vol.8, p.83, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01215533

B. Dehay, Pathogenic lysosomal depletion in Parkinson's disease, J Neurosci, vol.30, issue.37, pp.12535-12544, 2010.

M. Xilouri and O. R. Brekk, Stefanis L. ?-Synuclein and protein degradation systems: a reciprocal relationship, Mol Neurobiol, vol.47, issue.2, pp.537-551, 2013.

C. T. Chu, J. Zhu, and R. Dagda, Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death, Autophagy, vol.3, issue.6, pp.663-666, 2007.

A. M. Cuervo, L. Stefanis, R. Fredenburg, P. T. Lansbury, and D. Sulzer, Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy, Science, vol.305, issue.5688, pp.1292-1295, 2004.

M. Martinez-vicente, Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy, J Clin Invest, vol.118, issue.2, pp.777-788, 2008.

T. Vogiatzi, M. Xilouri, K. Vekrellis, and L. Stefanis, Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells, J Biol Chem, vol.283, issue.35, pp.23542-23556, 2008.

A. Scrivo, M. Bourdenx, O. Pampliega, and A. M. Cuervo, Selective autophagy as a potential therapeutic target for neurodegenerative disorders, Lancet Neurol, vol.17, issue.9, pp.802-815, 2018.

D. Ebrahimi-fakhari, Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of ?-synuclein, J Neurosci, vol.31, issue.41, pp.14508-14520, 2011.

H. J. Lee, F. Khoshaghideh, S. Patel, and S. J. Lee, Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway, J Neurosci, vol.24, issue.8, pp.1888-1896, 2004.

P. O. Fernagut, Multiple system atrophy: a prototypical synucleinopathy for disease-modifying therapeutic strategies, Neurobiol Dis, vol.67, pp.133-139, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01217333

L. Schwarz, O. Goldbaum, M. Bergmann, S. Probst-cousin, and C. Richter-landsberg, Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes, J Mol Neurosci, vol.47, issue.2, pp.256-266, 2012.

K. Tanji, Alteration of autophagosomal proteins in the brain of multiple system atrophy, Neurobiol Dis, vol.49, pp.190-198, 2013.

M. Compagnoni and G. , Mitochondrial Dysregulation and Impaired Autophagy in iPSC-Derived Dopaminergic Neurons of Multiple System Atrophy, Stem Cell Reports, vol.11, issue.5, pp.1185-1198, 2018.

W. Song, TFEB regulates lysosomal proteostasis, Hum Mol Genet, vol.22, issue.10, pp.1994-2009, 2013.

C. J. Cortes, L. Spada, and A. R. , TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities, Neurobiol Dis, vol.122, pp.83-93, 2019.

M. Palmieri, Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways, Hum Mol Genet, vol.20, pp.3852-3866, 2011.

H. Martini-stoica, Y. Xu, A. Ballabio, and H. Zheng, The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective, Trends Neurosci, vol.39, issue.4, pp.221-234, 2016.

C. Settembre, TFEB links autophagy to lysosomal biogenesis, Science, vol.332, issue.6036, pp.1429-1433, 2011.

C. Settembre, A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB, EMBO J, vol.31, issue.5, pp.1095-1108, 2012.

M. Decressac, B. Mattsson, P. Weikop, M. Lundblad, J. Jakobsson et al., TFEB-mediated autophagy rescues midbrain dopamine neurons from ?-synuclein toxicity, Proc Natl Acad Sci, vol.110, pp.1817-1826, 2013.

K. Kilpatrick, Y. Zeng, T. Hancock, and L. Segatori, Genetic and chemical activation of TFEB mediates clearance of aggregated alpha-synuclein, PLoS One, vol.10, issue.3, p.120819, 2015.

W. Song, F. Wang, P. Lotfi, M. Sardiello, and L. Segatori, 2-Hydroxypropyl-?-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy, J Biol Chem, vol.289, issue.14, pp.10211-10222, 2014.

A. Torra, Overexpression of TFEB Drives a Pleiotropic Neurotrophic Effect and Prevents Parkinson's Disease-Related Neurodegeneration, Mol Ther, vol.26, issue.6, pp.1552-1567, 2018.

M. Bourdenx, Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by ?-synuclein overexpression, Acta Neuropathol Commun, vol.3, p.46, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01193129

H. Wang, R. Wang, S. Xu, and M. K. Lakshmana, Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer's and Amyotrophic Lateral Sclerosis Brains, Neurosci J, p.4732837, 2016.

F. Bassil, Insulin resistance and exendin-4 treatment for multiple system atrophy, Brain, vol.140, issue.5, pp.1420-1436, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01537233

F. Bassil, Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy, Proc Natl Acad Sci, vol.113, issue.34, pp.9593-9598, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01370967

P. O. Fernagut, Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy, Synapse, vol.68, issue.3, pp.98-106, 2014.

P. J. Kahle, Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes, EMBO Rep, vol.3, issue.6, pp.583-588, 2002.

V. Refolo, Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies, Acta Neuropathol Commun, vol.6, issue.1, p.2, 2018.

G. Napolitano, mTOR-dependent phosphorylation controls TFEB nuclear export, Nat Commun, vol.9, issue.1, p.3312, 2018.

R. Puertollano, S. M. Ferguson, J. Brugarolas, and A. Ballabio, The complex relationship between TFEB transcription factor phosphorylation and subcellular localization, EMBO J, vol.37, issue.11, p.98804, 2018.

R. Filograna, Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation, PLoS ONE, vol.10, issue.8, p.136769, 2015.

S. L. Hsuan, H. M. Klintworth, and Z. Xia, Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways, J Neurosci, vol.26, issue.17, pp.4481-4491, 2006.

P. Boya and G. Kroemer, Lysosomal membrane permeabilization in cell death, Oncogene, vol.27, issue.50, pp.6434-6451, 2008.

M. Vila, J. Bove?, B. Dehay, N. Rodríguez-muela, and P. Boya, Lysosomal membrane permeabilization in Parkinson disease, Autophagy, vol.7, issue.1, pp.98-100, 2011.

M. Bourdenx and B. Dehay, What lysosomes actually tell us about Parkinson's disease?, Ageing Res Rev, vol.32, pp.140-149, 2016.

P. Lie and R. A. Nixon, Lysosome trafficking and signaling in health and neurodegenerative diseases, Neurobiol Dis, vol.122, pp.94-105, 2019.

M. Xilouri, Boosting chaperone-mediated autophagy in vivo mitigates ?-synuclein-induced neurodegeneration, Brain, vol.136, pp.2130-2146, 2013.

B. Spencer, Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases, J Neurosci, vol.29, issue.43, pp.13578-13588, 2009.

B. Boland, Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing, Nat Rev Drug Discov, vol.17, issue.9, pp.660-688, 2018.

E. Valera and E. Masliah, The neuropathology of multiple system atrophy and its therapeutic implications, Auton Neurosci, vol.211, pp.1-6, 2018.

D. Malta and C. , Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth, Science, vol.356, issue.6343, pp.1188-1192, 2017.

A. I. Flores, Constitutively active Akt induces enhanced myelination in the CNS, J Neurosci, vol.28, issue.28, pp.7174-7183, 2008.

M. Bradl and H. Lassmann, Oligodendrocytes: biology and pathology, Acta Neuropathol, vol.119, issue.1, pp.37-53, 2010.

J. M. Gaesser and S. L. Fyffe-maricich, Intracellular signaling pathway regulation of myelination and remyelination in the CNS, Exp Neurol, vol.283, pp.501-511, 2016.

L. Fellner, E. Buchinger, D. Brueck, R. Irschick, G. K. Wenning et al., Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived ?-synuclein in oligodendroglia: implications for MSA pathogenesis, BMC Neurosci, vol.19, issue.1, p.32, 2018.

I. Carballo-carbajal, Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis, Nat Commun, vol.10, issue.1, p.973, 2019.

H. Martini-stoica, TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading, J Exp Med, vol.215, issue.9, pp.2355-2377, 2018.

C. Spampanato, Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease, EMBO Mol Med, vol.5, issue.5, pp.691-706, 2013.

Y. Liu, Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia, Autophagy, vol.15, issue.3, pp.493-509, 2019.

S. Bala and G. Szabo, TFEB, a master regulator of lysosome biogenesis and autophagy, is a new player in alcoholic liver disease, Dig Med Res, vol.1, p.16, 2018.

X. Chao, H. M. Ni, and W. X. Ding, Insufficient autophagy: a novel autophagic flux scenario uncovered by impaired liver TFEB-mediated lysosomal biogenesis from chronic alcohol-drinking mice, Autophagy, vol.14, issue.9, pp.1646-1648, 2018.

G. Zheng, TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation, Cell Death Dis, vol.9, issue.9, p.858, 2018.

S. Tan, Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy, Sci Rep, vol.9, issue.1, p.727, 2019.

S. Zolotukhin, Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield, Gene Ther, vol.6, issue.6, pp.973-985, 1999.

C. Aurnhammer, Universal real-time PCR for the detection and quantification of adeno-associated virus serotype 2-derived inverted terminal repeat sequences, Hum Gene Ther Methods, vol.23, issue.1, pp.18-28, 2012.

M. Engeln, Levodopa gains psychostimulant-like properties after nigral dopaminergic loss, Ann Neurol, vol.74, issue.1, pp.140-144, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01153692

P. Chomczynski and N. Sacchi, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal Biochem, vol.162, issue.1, pp.156-159, 1987.

S. A. Bustin, The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments, Clin Chem, vol.55, issue.4, pp.611-622, 2009.

K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method, Methods, vol.25, issue.4, pp.402-408, 2001.

A. Recasens, Lewy body extracts from Parkinson disease brains trigger ?-synuclein pathology and neurodegeneration in mice and monkeys, Ann Neurol, vol.75, issue.3, pp.351-362, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01022197

J. D. Hunter, Matplotlib: A 2D Graphics Environment, 2007.

E. Jones, T. Oliphant, P. Peterson, and . Scipy, Open Source Scientific Tools for Python, 2001.

W. S. Van-der, S. C. Colbert, and G. Varoquaux, The NumPy Array: A Structure for Efficient Numerical Computation, Computing in Science and Engineering, vol.13, issue.2, pp.22-30, 2011.
URL : https://hal.archives-ouvertes.fr/inria-00564007