The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines, Cancer, vol.104, pp.1129-1166, 2005. ,
Advances in radiation oncology, Annu Rev Med, vol.57, pp.19-31, 2006. ,
Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: analysis of 101 published survival curves, Int J Radiat Oncol Biol Phys, vol.11, pp.1699-707, 1985. ,
Intrinsic radiation sensitivity may not be the major determinant of the poor clinical outcome of glioblastoma multiforme, Int J Radiat Oncol Biol Phys, vol.25, issue.93, p.90345, 1993. ,
Tumor cell radiosensitivity is a major determinant of tumor response to radiation, Cancer Res, vol.66, pp.8352-8357, 2006. ,
DNA double-strand breaks: signaling, repair and the cancer connection, Nat Genet, vol.27, pp.247-54, 2001. ,
The level of induced DNA double-strand breakage correlates with cell killing after X-irradiation, Int J Radiat Biol Relat Stud Phys Chem Med, vol.48, pp.45-54, 1985. ,
Cellular radiosensitivity: how much better do we understand it?, Int J Radiat Biol, vol.85, pp.1061-81, 2009. ,
The role of double-strand break repair -insights from human genetics, Nat Rev Genet, vol.7, pp.45-54, 2006. ,
DNA repair pathways as targets for cancer therapy, Nat Rev Cancer, vol.8, pp.193-204, 2008. ,
Biomarkers of response and resistance to DNA repair targeted therapies, Clin Cancer Res, vol.22, pp.5651-60, 2016. ,
Strategies to improve radiotherapy with targeted drugs, Nat Rev Cancer, vol.11, pp.239-53, 2011. ,
DNA repair targeting and radiotherapy: a focus on the therapeutic ratio, Semin Radiat Oncol, vol.20, pp.217-239, 2010. ,
State-of-the-art strategies for targeting the DNA damage response in cancer, Nat Rev Clin Oncol, vol.16, pp.81-104, 2019. ,
Cell-cycle checkpoints and cancer, Nature, vol.432, pp.316-339, 2004. ,
DNA repair dysregulation from cancer driver to therapeutic target, Nat Rev Cancer, vol.12, pp.801-818, 2012. ,
Synthetic lethality: exploiting the addiction of cancer to DNA repair, Blood, vol.117, pp.6074-82, 2011. ,
Role of oxidative stress and DNA damage in human carcinogenesis, Mutat Res, vol.711, pp.193-201, 2011. ,
Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues, Mutat Res, vol.674, pp.131-137, 2009. ,
The DNA-damage response in human biology and disease, Nature, vol.461, pp.1071-1079, 2009. ,
DNA damage and repair, Basic Life Sci, vol.58, pp.403-418, 1991. ,
Damage pattern as a function of radiation quality and other factors, C R Acad Sci III, Sci Vie, vol.322, pp.89-101, 1999. ,
Single-strand interruptions in replicating chromosomes cause double-strand breaks, Proc Natl Acad Sci, vol.98, pp.8241-8247, 2001. ,
A preclinical study combining the DNA repair inhibitor Dbait with radiotherapy for the treatment of melanoma, Neoplasia, vol.16, pp.835-879, 2014. ,
DNA repair: from genome maintenance to biomarker and therapeutic target, Clin Cancer Res, vol.17, pp.6973-84, 2011. ,
Base excision repair, Cold Spring Harb Perspect Biol, vol.5, p.12583, 2013. ,
Oxygen as a friend and enemy: how to combat the mutational potential of 8-oxo-guanine, DNA Repair, vol.9, pp.604-620, 2010. ,
Targeting BER enzymes in cancer therapy, DNA Repair, vol.71, pp.118-144, 2018. ,
Targeting base excision repair as a sensitization strategy in radiotherapy, Semin Radiat Oncol, vol.20, pp.241-250, 2010. ,
Radiation sensitivity depends on OGG1 activity status in human leukemia cell lines, Free Radic Biol Med, vol.32, pp.212-232, 2002. ,
Attempted base excision repair of ionizing radiation damage in human lymphoblastoid cells produces lethal and mutagenic double strand breaks, DNA Repair, vol.3, pp.1323-1357, 2004. ,
Base damage and single-strand break repair: mechanisms and functional significance of short-and long-patch repair subpathways, DNA Repair, vol.6, pp.398-409, 2007. ,
Base excision repair, a pathway regulated by posttranslational modifications, Mol Cell Biol, vol.36, pp.1426-1463, 2016. ,
Base excision repair: a critical player in many games, DNA Repair, vol.19, pp.14-26, 2014. ,
BERing the burden of damage: pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management, DNA Repair, vol.56, pp.51-64, 2017. ,
DNA glycosylases: in DNA repair and beyond, Chromosoma, vol.121, pp.1-20, 2012. ,
Oxidatively induced DNA damage and its repair in cancer, Mutat Res Rev Mutat Res, vol.763, pp.212-257, 2015. ,
PARP-1 regulates DNA repair factor availability, EMBO Mol Med, vol.10, p.8816, 2018. ,
Nucleotide excision repair polymorphisms may modify ionizing radiationrelated breast cancer risk in US radiologic technologists, Int J Cancer, vol.123, pp.2713-2719, 2008. ,
DNA double-strand break repair: all's well that ends well, Annu Rev Genet, vol.40, pp.363-83, 2006. ,
Involvement of nucleotide excision and mismatch repair mechanisms in double strand break repair, Curr Genomics, vol.10, pp.250-258, 2009. ,
Radiation-induced DNA repair foci: spatio-temporal aspects of formation, application for assessment of radiosensitivity and biological dosimetry, Mutat Res, vol.704, pp.132-173, 2010. ,
Replication-coupled DNA repair, Mol Cell, vol.74, pp.866-76, 2019. ,
Nonhomologous DNA end-joining for repair of DNA double-strand breaks, J Biol Chem, vol.293, pp.10512-10535, 2018. ,
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair, J Cell Biol, vol.202, pp.579-95, 2013. ,
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen, Cell, vol.72, issue.93, p.90057, 1993. ,
DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner, Nucleic Acids Res, vol.31, pp.6819-6846, 2003. ,
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination, Cell, vol.108, pp.781-94, 2002. ,
Ku recruits the XRCC4-ligase IV complex to DNA ends, Mol Cell Biol, vol.20, pp.2996-3003, 2000. ,
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining, Cell, vol.124, pp.301-314, 2006. ,
Repair of DNA double-strand breaks by mammalian alternative end-joining pathways, J Biol Chem, vol.293, pp.10536-10582, 2018. ,
MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings, Trends Genet, vol.24, pp.529-567, 2008. ,
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70, Proc Natl Acad Sci, vol.107, pp.3034-3043, 2010. ,
IgH class switching and translocations use a robust non-classical end-joining pathway, Nature, vol.449, pp.478-82, 2007. ,
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites, J Biol Chem, vol.283, pp.1197-208, 2008. ,
A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage, Nucleic Acids Res, vol.31, pp.5526-5559, 2003. ,
Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase ?, Nat Struct Mol Biol, vol.22, pp.230-237, 2015. ,
The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks, DNA Repair, vol.3, pp.1515-1535, 2004. ,
Human CtIP promotes DNA end resection, Nature, vol.450, pp.509-523, 2007. ,
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins, Cold Spring Harb Perspect Biol, vol.7, p.16600, 2015. ,
Rad54: the Swiss Army knife of homologous recombination?, Nucleic Acids Res, vol.34, pp.4115-4140, 2006. ,
Rad54 protein stimulates the postsynaptic phase of Rad51 protein-mediated DNA strand exchange, Proc Natl Acad Sci, vol.98, pp.8447-53, 2001. ,
Error-prone repair of DNA double-strand breaks, J Cell Physiol, vol.231, pp.15-24, 2016. ,
DNA double-strand break repair-pathway choice in somatic mammalian cells, Nat Rev Mol Cell Biol, 2019. ,
Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells, PLoS Genet, vol.6, p.1000855, 2010. ,
Harnessing synthetic lethal interactions in anticancer drug discovery, Nat Rev Drug Discov, vol.10, pp.351-64, 2011. ,
Targeting DNA repair in cancer: beyond PARP inhibitors, Cancer Discov, vol.7, pp.20-37, 2017. ,
Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study, Lancet Oncol, vol.12, pp.852-61, 2011. ,
Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer, J Clin Oncol, vol.30, pp.372-381, 2012. ,
Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer, N Engl J Med, vol.366, pp.1382-92, 2012. ,
Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361, J Natl Cancer Inst, vol.96, pp.56-67, 2004. ,
Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-Ribose) polymerase: mechanisms and therapeutic potential, Int J Radiat Oncol Biol Phys, vol.72, pp.1188-97, 2008. ,
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models, Clin Cancer Res, vol.13, pp.2728-2765, 2007. ,
A final report of a phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy (LDFWAR) in patients with advanced solid malignancies and peritoneal carcinomatosis with a dose escalation in ovarian and fallopian tube cancers, Gynecol Oncol, vol.144, pp.486-90, 2017. ,
Veliparib in combination with whole-brain radiation therapy for patients with brain metastases from non-small cell lung cancer: results of a randomized, global, placebo-controlled study, J Neurooncol, vol.131, pp.105-120, 2017. ,
Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a pediatric brain tumor consortium report, Neuro-oncology, vol.9, pp.145-60, 2007. ,
Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study, Lancet Oncol, vol.11, issue.10, pp.70058-70067, 2010. ,
Epigenetic therapy and cisplatin chemoradiation in FIGO stage IIIB cervical cancer, Eur J Gynaecol Oncol, vol.31, pp.386-91, 2010. ,
Firstin-human phase I study of the DNA-repair inhibitor DT01 in combination with radiotherapy in patients with skin metastases from melanoma, Br J Cancer, vol.114, pp.1199-205, 2016. ,
Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment, Cell Mol Life Sci, vol.67, pp.3589-608, 2010. ,
Radiation resistance in glioma cells determined by DNA damage repair activity of Ape1/Ref-1, J Radiat Res, vol.51, pp.393-404, 2010. ,
Chimeric adenoviral vector Ad5/F35-mediated APE1 siRNA enhances sensitivity of human colorectal cancer cells to radiotherapy in vitro and in vivo, Cancer Gene Ther, vol.15, pp.625-660, 2008. ,
DNA-PK as an emerging therapeutic target in cancer, Front Oncol, vol.9, p.635, 2019. ,
SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization, Oncogene, vol.23, pp.873-82, 2004. ,
DNAdependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs, Cancer Res, vol.65, pp.4987-992, 2005. ,
Small molecules, inhibitors of DNA-PK, targeting DNA repair, and beyond, Front Pharmacol, vol.4, p.5, 2013. ,
beware of clinical trials of DNA repair inhibitors, Int J Radiat Oncol Biol Phys, vol.103, pp.1182-1185, 2019. ,
clinical activity and pharmacological biomarker evaluation of the DNA-dependent protein kinase (DNA-PK) inhibitor M3814: results from two phase I trials, Ann Oncol, p.29, 2018. ,
Inhibition of non-homologous end joining repair impairs pancreatic cancer growth and enhances radiation response, PLoS ONE, vol.7, p.39588, 2012. ,
DNA repair targeted therapy: The past or future of cancer treatment?, Pharmacol Ther, vol.160, pp.65-83, 2016. ,
Phase I trial of a dual TOR kinase and DNA-PK inhibitor (CC-115) in advanced solid and hematologic cancers, JCO, vol.34, p.2505, 2016. ,
The hallmarks of cancer, Cell, vol.100, pp.57-70, 2000. ,
Imatinib radiosensitizes bladder cancer by targeting homologous recombination, Cancer Res, vol.73, pp.1611-1631, 2013. ,
Regulation of DNA double-strand break repair pathway choice, Cell Res, vol.18, pp.134-181, 2008. ,
Loss of atm radiosensitizes multiple p53 null tissues, Cancer Res, vol.58, pp.5637-5646, 1998. ,
Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation, Cancer Res, vol.68, pp.7466-74, 2008. ,
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM, Cancer Res, vol.64, pp.9152-9161, 2004. ,
Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control, Cell Cycle, vol.11, pp.1167-73, 2012. ,
Deletion of Atm in tumor but not endothelial cells improves radiation response in a primary mouse model of lung adenocarcinoma, Cancer Res, vol.79, pp.773-82, 2019. ,
New rationales for using TGFbeta inhibitors in radiotherapy, Int J Radiat Biol, vol.83, pp.803-814, 2007. ,
Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair, DNA Repair, vol.8, pp.253-61, 2009. ,
Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response, Cancer Res, vol.67, pp.1046-53, 2007. ,
Dancing with the DNA damage response: next-generation anti-cancer therapeutic strategies, Ther Adv Med Oncol, vol.10, p.1758835918786658, 2018. ,
Targeting the ATR-CHK1 axis in cancer therapy, Cancers, vol.9, p.41, 2017. ,
The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATMdeficient non-small cell lung cancer in vivo, Oncotarget, vol.6, pp.44289-305, 2015. ,
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex, Nat Chem Biol, vol.4, pp.119-144, 2008. ,
Ataxia-telangiectasia mutated and the Mre11-Rad50-NBS1 complex: promising targets for radiosensitization, Acta Med Okayama, vol.66, pp.83-92, 2012. ,
Small-molecule drugs mimicking DNA damage: a new strategy for sensitizing tumors to radiotherapy, Clin Cancer Res, vol.15, pp.1308-1324, 2009. ,
Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage response, PLoS ONE, vol.4, p.6298, 2009. ,
Inhibition of DNA damage repair by artificial activation of PARP with siDNA, Nucleic Acids Res, vol.41, pp.7344-55, 2013. ,
Combining the DNA repair inhibitor Dbait with radiotherapy for the treatment of high grade glioma: efficacy and protein biomarkers of resistance in preclinical models, Front Oncol, vol.9, p.549, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02180772
Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair, Br J Cancer, vol.108, pp.748-54, 2013. ,
Loss of ARID1A in tumor cells renders selective vulnerability to combined ionizing radiation and PARP inhibitor therapy, Clin Cancer Res, vol.25, pp.5584-94, 2019. ,
Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibition, Int J Radiat Oncol Biol Phys, vol.78, pp.237-282, 2010. ,
Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair, Proc Natl Acad Sci, vol.107, pp.14639-14683, 2010. ,
Adamantanyl-histone deacetylase inhibitor H6CAHA exhibits favorable pharmacokinetics and augments prostate cancer radiation sensitivity, Int J Radiat Oncol Biol Phys, vol.79, pp.1541-1549, 2011. ,
Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci, Mol Cancer Ther, vol.5, pp.1967-74, 2006. ,
Sorafenib potentiates irradiation effect in hepatocellular carcinoma in vitro and in vivo, Cancer Lett, vol.329, pp.109-126, 2013. ,
Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways, Radiother Oncol, vol.105, pp.241-250, 2012. ,
A phase I study of dasatinib with concurrent chemoradiation for stage III non-small cell lung cancer, Front Oncol, vol.2, p.56, 2012. ,
Toxicity of concurrent stereotactic radiotherapy and targeted therapy or immunotherapy: a systematic review, Cancer Treatment Rev, vol.53, pp.25-37, 2017. ,
EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment, Cancer Res, vol.71, pp.1103-1117, 2011. ,
Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma, Cancer Res, vol.62, pp.7350-7356, 2002. ,
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck, N Engl J Med, vol.354, pp.567-78, 2006. ,
Cisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: a randomized phase II trial, J Clin Oncol, vol.31, pp.1415-1436, 2013. ,
Interaction of radiation and gefitinib on a human lung cancer cell line with mutant EGFR gene in vitro, Anticancer Res, vol.32, pp.4877-81, 2012. ,
Targeting DNA damage and repair: embracing the pharmacological era for successful cancer therapy, Pharmacol Ther, vol.133, pp.334-50, 2012. ,
In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762, Clin Cancer Res, vol.16, pp.2076-84, 2010. ,
AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies, Mol Cancer Ther, vol.7, pp.2955-66, 2008. ,
Combining Chk1/2 inhibition with cetuximab and radiation enhances in vitro and in vivo cytotoxicity in head and neck squamous cell carcinoma, Mol Cancer Ther, vol.16, pp.591-600, 2017. ,
The DNA damage response: implications for tumor responses to radiation and chemotherapy, Annu Rev Med, vol.66, pp.129-172, 2015. ,
The DNA damage response: making it safe to play with knives, Mol Cell, vol.40, pp.179-204, 2010. ,
Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair, Cancer Res, vol.70, pp.4972-81, 2010. ,
WEE1 kinase as a target for cancer therapy, JCO, vol.12, pp.3159-64, 2015. ,
MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells, Clin Cancer Res, vol.17, pp.5638-5686, 2011. ,
WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas, Mol Cancer Ther, vol.12, pp.141-50, 2013. ,
Radiation therapy to enhance tumor immunotherapy: a novel application for an established modality, Int J Radiat Biol, vol.95, pp.936-945, 2019. ,
Radiotherapy and immunogenic cell death, Semin Radiat Oncol, vol.25, pp.11-18, 2015. ,
Clinical development of novel drug-radiotherapy combinations, Clin Cancer Res, vol.25, pp.1455-61, 2019. ,