Deleting a Chromatin Remodeling Gene Increases the Diversity of Secondary Metabolites Produced by Colletotrichum higginsianum - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Natural Products Année : 2019

Deleting a Chromatin Remodeling Gene Increases the Diversity of Secondary Metabolites Produced by Colletotrichum higginsianum

Résumé

Colletotrichum higginsianum is the causal agent of crucifer anthracnose disease, responsible for important economic losses in Brassica crops. A mutant lacking the CclA subunit of the COMPASS complex was expected to undergo chromatin decondensation and the activation of cryptic secondary metabolite biosynthetic gene clusters. Liquid-state fermentation of the Δ cclA mutant coupled with in situ solid-phase extraction led to the production of three families of compounds, namely, colletorin and colletochlorin derivatives with two new representatives, colletorin D (1) and colletorin D acid (2), the diterpenoid α-pyrone higginsianin family with two new analogues, higginsianin C (3) and 13- epi-higginsianin C (4), and sclerosporide (5) coupling a sclerosporin moiety with dimethoxy inositol.
Fichier principal
Vignette du fichier
Dallery_JNatProd_2019_813_with_SI.pdf (2.41 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02346243 , version 1 (10-03-2021)

Identifiants

Citer

Jean-Felix Dallery, Géraldine Le Goff, Emilie Adelin, Bogdan Iorga, Sandrine Pigné, et al.. Deleting a Chromatin Remodeling Gene Increases the Diversity of Secondary Metabolites Produced by Colletotrichum higginsianum. Journal of Natural Products, 2019, 82 (4), pp.813-822. ⟨10.1021/acs.jnatprod.8b00796⟩. ⟨hal-02346243⟩
180 Consultations
147 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More