Changes in Blood B Cell Phenotypes and Epstein‐Barr Virus Load in Chronically Human Immunodeficiency Virus–Infected Patients before and after Antiretroviral Therapy

Yolande Richard (1) , Corinne Amiel (2) , Vincent Jeantils , Denis Mestivier (3) , Alain Portier (4) , Guy Dhello , Jean Feuillard (5) , Rita Creidy (6) , Jean‐claude Nicolas , Martine Raphaël (7)

1 IC UM3 (UMR 8104 / U1016) - Institut Cochin
2 CHU Tenon [AP-HP]
3 IJM (UMR_7592) - Institut Jacques Monod
4 Régulation de la survie cellulaire et des allogreffes
5 PMRIL - Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations
6 NICN - Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN
7 Laboratoire d'Hématologie

Because transitional-like B cells persist concomitantly with high EBV load after highly active antiretroviral therapy, we suggest that this population might be an alternative EBV reservoir in patients with chronic HIV infection who have strongly reduced numbers of memory B cells. The consequences of EBV infection of immature B cells are discussed with regard to B cell maturation and a higher prevalence of B cell lymphoma in HIV‐infected patients.

Domaines: Immunologie; Immunité adaptative; Médecine humaine et pathologie; Maladies infectieuses; Microbiologie et Parasitologie; Virologie

Yolande Richard, Corinne Amiel, Vincent Jeantils, Denis Mestivier, Alain Portier, et al.. Changes in Blood B Cell Phenotypes and Epstein‐Barr Virus Load in Chronically Human Immunodeficiency Virus–Infected Patients before and after Antiretroviral Therapy. Journal of Infectious Diseases, 2010, 202 (9), pp.1424-1434. ⟨10.1086/656479⟩. ⟨hal-02346167⟩