Systemic Therapy in Advanced Thymic Epithelial Tumors: Insights from the RYTHMIC Prospective Cohort

Claire Merveilleux Du Vignaux , Eric Dansin , Laurent Mhanna , Laurent Greillier , Eric Pichon , Mallorie Kerjouan , Christelle Clément-Duchêne , Bertrand Mennecier , Virginie Westeel , Marie Robert , Xavier Quantin , Gérard Zalcman , Luc Thiberville (1) , Hervé Léna , Thierry J. Molina , Fabien Calcagno , Pierre Fournel , Julien Mazières , Benjamin Besse , Nicolas Girard

1 QuantIF-LITIS - Equipe Quantification en Imagerie Fonctionnelle

Thymic epithelial tumors (TETs) are rare malignancies that may be aggressive and difficult to treat. In the advanced setting, systemic treatments may be delivered as primary therapy before surgery or definitive radiotherapy, as exclusive treatment when no focal treatment is feasible, or in the setting of recurrences. Réseau tumeurs THYMIques et Cancer (RYTHMIC) is the nationwide network for TETs in France. The objective of the study was to describe the modalities and analyze the efficacy of systemic treatments for patients with advanced TETs included in the RYTHMIC prospective database hosted by the French Thoracic Cancer Intergroup.

ClinicalTrials.gov Identifier NCT01822795 .

Mots clés: Coil treatment; Cost-effectiveness; QALY; Severe emphysema; Chemotherapy; Network; Recurrence; Thymic Carcinoma; Thymoma

Domaines: Sciences du Vivant [q-bio]

Claire Merveilleux Du Vignaux, Eric Dansin, Laurent Mhanna, Laurent Greillier, Eric Pichon, et al.. Systemic Therapy in Advanced Thymic Epithelial Tumors: Insights from the RYTHMIC Prospective Cohort. Journal of Thoracic Oncology, 2018, 13 (11), pp.1762-1770. ⟨10.1016/j.jtho.2018.08.005⟩. ⟨hal-02345221⟩