. Rt-qpcr, Total RNA was quantified on an ND-100 NanoDrop and samples were stored at -80 °C. Total RNA was diluted to 50 ng/pL (final concentra tion) and 500 ng was used to perform RT-PCR. cDNAs were loaded on customized TLDA. The PCR protocol was as follows: a preparation step (50 °C for two minutes followed by 10 min at 94.5 °C), then 40 cycles including denaturation (97 °C, 3 min), hybridization of primers and elongation (60 °C, 1 min), The Taqman Low Density Assay (TLDA) includes the following list of genes: Hs00909449_m1 (ACTA2), Hs00248075_m1 (BBC3), Hs00978503_ m1 (BIRC5), Hs01075861_m1 (CD44), Hs00938777_m1 (CDK1), Hs00355782_m1 (CDKN1A), Hs00923894_ m1 (CDKN2A), Hs00929873_m1 (CSF2), Hs99999083_m1 (CSF3), Hs00236330_m1 (FAS), Hs00169255_m1 (GADD45A), Hs00232622_m1 (HEY2), Hs01555410_m1 (IL1B), Hs00985639_m1 (IL6), Hs00174103_m1 (IL8), Hs00765730_m1 (NFKB1), Hs01126606_m1 (SERPINE1), Hs00998193_m1 (SMAD7), Hs00162558_m1 (TAGLN), Hs00936520_m1 (TP53I3), Hs00426287_m1 (IGFBP3), Hs00181213_m1 (IGFBP5), Hs00266026_m1 (IGFBP7), Hs01042796_m1 (MMP7), Hs00233987_m1 (MMP10), Hs00176481_m1 (CDKN2D), p.971716

, m1 (CAV1), Hs01597588_m1 (CDKN1B), Hs00793225_m1 (CDKN2B), Hs00914223_m1 (EP300), Hs01059210_ m1 (LMNB1), Hs01062014_m1 (NOTCH1), Hs01100061_m1 (PAK4), Hs01078066_m1 (RB1), Hs01009006_m1 (SIRT1), Hs00187842_m1 (B2m), Hs01119326_m1 (PTPRJ), Hs00190266_m1 (STX4), Hs00247916_m1 (LAT2), Hs00601975_m1 (CXCL2), Hs00174092_m1 (IL1A), Hs00989786_m1 (CEACAM1), Hs00174583_m1 (SELp), Hs00232219_m1 (SMAD3), Hs99999903_m1 (ACTB), Hs99999906_m1 (PGK1), Hs00177083_m1 (MAPK8)

, Analysis of data was performed using ExpressionSuite software (THERMO FISHER SCIENTIFIC), while representation and statistical analysis of the data were performed using DataAssist software

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