,
, , vol.5
, , vol.10
, 24 g, 10.3 mmol) was added. The reaction mixture was stirred at 40 °C for 23 h. After cooling to room temperature and addition of dichloromethane (160 mL), the resulting solution was washed with deionised water (2 x 80 mL). The organic layer was dried over magnesium sulfate, filtered and evaporated under reduced pressure. The crude product was purified by column chromatography (SiO 2 , ethyl acetate/cyclohexane, 1/9, v/v) to give compound 16 as a pale yellow oil (2.92 g, 4.20 mmol) along with recovered starting material (1.36 g, 2.90 mmol), /v) indicated incomplete reaction process, the mixture was cooled to room temperature and additional di-tert-butyl dicarbonate, p.19, 1136.
, Yield: 76%; mp 78-80 °C, g, 1.27 mmol), pp.1008-1009, 1105.
, Hz), 1.20 (m, 6H), 1.36 (s, 18H), 1.47 (s, 9H), 3.24 (m, 2H), 3.70 (m, 4H), 4.81 (q, 1H, J = 5.7, 9.2 Hz), 5.20 (m, 3H), vol.5, pp.3-117
, CDCl 3 ) ? -8.3 (3C, 1 J C-119 Sn = 349 Hz, 1 J C-117 Sn = 333 Hz), 15.1 (2C), vol.13
, 1C, 3 J C-117-119 Sn = 43.4 Hz), 134.8, 139.5 (1C, 3 J C-117-119 Sn = 32 Hz, vol.124, p.67
, 43 (s, 18H), 1.48 (s, 9H), 3.32 (dd, 1H, J = 8.5, 14, vol.1
, 13 C NMR (50.32 MHz, CDCl 3 ) ??15.1 (2C), 28.1 (9C), pp.19-470
, (ethoxymethoxy)-2-iodophenyl)-2-(di(tert-2 , dichloromethane/ethanol, 95/5, v/v). The pure compound 18b, obtained as an off-white solid, was carefully dried under vacuum (266 mg, 0.28 gaseous atmosphere, CDCl 3 ) ??-76.3 ppm; HRMS: m/z, vol.4, pp.1110-1111, 1137.
, 47 (s, 27H), 3.30 (m, 1H), 3.5-3.8 (m, 5H), 3.83 (s, 3H, 4.95 (m, 1H), 5.18 (m, 2H), vol.1
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