Conventional Matrices Loaded Onto a Graphene Layer Enhances MALDI-TOF/TOF Signal: Its Application to Improve Detection of Phosphorylated Peptides

Carlos Rodriguez 1 Javier Palacios 1 Ignacio Fajardo 1, 2 José Luis Urdiales 1, 2 Xavier Le Guével 3 Jose Lozano 1 Francisca Sánchez-Jiménez 1, 2
1 Universidad de Málaga [Málaga]
2 CIBER de Enfermedades Raras (CIBERER)
3 Cancer Targets & Experimental Therapeutics
Abstract : This is the first study where graphene is used as a MALDI adjuvant in combination with the traditional matrix α-cyano-4-hydroxycinnamic acid (CHCA) to improve the signal intensity of peptide samples. Use of this amended matrix not only leads to increased signals but also to a higher number of peaks detected in complex samples. Additionally, the use of graphene has a stabilizing effect that can also be exploited to improve the detection of easily cleavable molecules.
Keywords : Phosphorylated peptides MALDI-TOF/TOF Graphene
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Submitted on : Tuesday, October 29, 2019 - 5:19:47 PM
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Carlos Rodriguez, Javier Palacios, Ignacio Fajardo, José Luis Urdiales, Xavier Le Guével, et al.. Conventional Matrices Loaded Onto a Graphene Layer Enhances MALDI-TOF/TOF Signal: Its Application to Improve Detection of Phosphorylated Peptides. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2016, 27 (2), pp.366-369. ⟨10.1007/s13361-015-1299-3⟩. ⟨hal-02338004⟩

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