Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice Studies

Elian Dupré (1) , Clément Danis (1, 2) , Alexis Arrial (3) , Xavier Hanoulle (1) , Mégane Homa (2) , François-Xavier Cantrelle (1) , Hamida Merzougui (1) , Morvane Colin (2) , Jean-Christophe Rain (3) , Luc Buée (2) , Isabelle Landrieu (1)

1 UGSF - Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576
2 JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
3 Hybrigenics [Paris]

Mots clés: Variable domain of the heavy-chain only antibodies; nanobodies; tauopathies; Alzheimer's disease; nuclear magnetic resonance spectroscopy

Domaines: Sciences du Vivant [q-bio]; Biochimie, Biologie Moléculaire

Elian Dupré, Clément Danis, Alexis Arrial, Xavier Hanoulle, Mégane Homa, et al.. Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice Studies. ACS Chemical Neuroscience, 2019, 10 (9), pp.3997-4006. ⟨10.1021/acschemneuro.9b00217⟩. ⟨hal-02337161⟩