Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results

Amandine Boulmier (1) , Xinxin Feng , Olivier Oms (1) , Pierre Mialane (1) , Eric Rivière (2) , Christopher Shin , Jiaqi Yao , Tadahiko Kubo , Taisuke Furuta , Eric Oldfield , Anne Dolbecq (1)

1 ILV - Institut Lavoisier de Versailles
2 ICMMO - Institut de Chimie Moléculaire et des Matériaux d'Orsay

We synthesized a series of polyoxometalate-bisphosphonate complexes containing Mo VI O 6 octahedra, zoledronate or an N-alkyl (n-C 6 or n-C 8) zoledronate analog, and in two cases, Mn as a heterometal. Mo 6 L 2 (L = Zol, ZolC 6 , ZolC 8) and Mo 4 L 2 Mn (L = Zol, ZolC 8) were

Domaines: Chimie

Amandine Boulmier, Xinxin Feng, Olivier Oms, Pierre Mialane, Eric Rivière, et al.. Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results. Inorganic Chemistry, 2017, 56 (13), pp.7558-7565. ⟨10.1021/acs.inorgchem.7b01114⟩. ⟨hal-02336688⟩