Synthesis and antibacterial activity of new 1,2,3-triazolylmethyl-2H-1,4-benzothiazin-3(4H)-one derivatives

Mohamed Ellouz (1) , Nada Kheira Sebbar (1) , Ismail Fichtali (2) , Younes Ouzidan (2) , Zakaria Mennane (3) , Reda Charof (3) , Joel Mague (4) , Martine Urrutigoity (5) , El Mokhtar Essassi (1, 6)

1 Faculté des sciences [Rabat]
2 USMBA - Université Sidi Mohamed Ben Abdellah
3 Institut National d'Hygiène [Maroc]
4 Tulane University
5 LCC - Laboratoire de chimie de coordination
6 Moroccan Foundation for Advanced Science, Innovation and Research (MASCIR)

A novel series of 1,2,3-triazole derivatives containing 1,4-benzothiazin-3-one ring (7a–9a, 7b–9b), (10a–12a, 10b–12b) and (13–15) were synthesized by 1,3-dipolar cycloaddition reactions of azides α-d-galactopyranoside azide F, 2,3,4,6-tetra-O-acetyl-(d)-glucopyranosyl azide G and methyl-N-benzoyl-α-azidoglycinate H with compounds 4–6.

Mots clés: 2; 3-Triazole; 1; 4-Benzothiazine; Antimicrobial activity; Cycloaddition; Spectroscopic methods

Domaines: Chimie de coordination

Mohamed Ellouz, Nada Kheira Sebbar, Ismail Fichtali, Younes Ouzidan, Zakaria Mennane, et al.. Synthesis and antibacterial activity of new 1,2,3-triazolylmethyl-2H-1,4-benzothiazin-3(4H)-one derivatives. Chemistry Central Journal, 2018, 12 (1), pp.123. ⟨10.1186/s13065-018-0494-2⟩. ⟨hal-02335843⟩